抗神经退行性疾病复方药物研究进展

Research progress in compound drugs for anti-neurodegenerative diseases

目的综述抗神经退行性疾病复方药物开发原则,总结近年来针对神经退行性疾病开发的复方药物,介绍复方药物作用机制,为神经退行性疾病复方药物研发提供参考。方法通过检索国内外相关文献及数据库,对已开发或进入临床试验的复方药物及药物作用机制进行整理、分析和归纳。结果目前已在受体抑制药、单克隆抗体药、神经保护药、炎症抑制药等药物的研究有显著进展,这些药物通过多靶点作用,能够改善记忆和认知能力,明显延缓疾病的发展进程,为提高神经退行性疾病患者的生活质量、改善患者运动状态带来了新的希望。结论抗神经退行性疾病复方药物具有显著治疗优势,但由于发病机制复杂、病程无法逆转等问题在开发过程中仍面临诸多挑战,生物信息技术、精准医疗和纳米递释系统等新兴技术的结合可为复方药物开发提供强大的技术支撑和创新动力。

Objective To review the principles of development of compound drugs for neurodegenerative diseases,summarize the related compound drugs developed in recent years and introduce their mechanism of action.Methods By searching relevant literature and databases at home and abroad,compound drugs and that have been developed or entered clinical trials and their mechanisms of action are summarized and analyzed.Results Significant progress has been made in the research on receptor suppressants,monoclonal antibody drugs,neuroprotective drugs and inflammatory suppressants.These drugs can improve memory and cognitive abilities through multi-target effects,significantly delay the progression of the disease,and bring new hopes for improving the quality of life of patients with neurodegenerative diseases and enhancing their motor function.Conclusion Compound drugs for treating neurodegenerative diseases have significant therapeutic advantages,but due to the complicated pathogenesis and irreversible course of disease,the development of these drugs remains challenging.The combination of emerging technologies such as bioinformatics technology,precision medicine,and nanodelivery systems can provide strong technical support and impetus of innovation for the development of compound drugs.