氯氮平联合碳酸锂治疗双相情感障碍躁狂症的临床效果

Clinical Effect of Clozapine Combined with Lithium Carbonate in the Treatment of Bipolar Disorder Mania

目的 探讨双相情感障碍(BD)躁狂症患者采用氯氮平联合碳酸锂治疗的临床效果。方法 选取2018年1月至2022年12月汝州市精神病医院收治的80例BD躁狂症患者,以随机数字表法分成对照组(40例)与研究组(40例),对照组采用碳酸锂治疗,研究组采用氯氮平联合碳酸锂治疗,比较两组临床疗效、症状严重程度[贝克-拉范森躁狂量表(BRMS)、阳性和阴性综合征量表(PANSS)]、生活质量[世界卫生组织生活质量量表(WHOQOL-100)]及不良反应。结果 研究组治疗有效率(95.00%)高于对照组(77.50%),差异有统计学意义(P <0.05);两组治疗2个月后BRMS、PANSS评分下降,且研究组BRMS、PANSS评分低于对照组,差异有统计学意义(P <0.05);两组治疗2个月后WHOQOL-100评分升高,且研究组WHOQOL-100评分高于对照组,差异有统计学意义(P <0.05);研究组不良反应发生率(10.00%)与对照组(15.00%)比较差异无统计学意义(P> 0.05)。结论 氯氮平联合碳酸锂用于治疗BD躁狂症,能够提高临床疗效,缓解临床症状,促进生活质量提升,可避免加重不良反应。

Objective To explore the clinical effect of clozapine combined with lithium carbonate in the treatment of bipolar disorder(BD)mania.Methods Eighty patients with BD mania admitted to Ruzhou Psychiatric Hospital from January 2018 to December 2022 were selected and randomly divided into a control group(n=40)and a study group(n=40).The control group was treated with lithium carbonate,while the study group was treated with clozapine combined with lithium carbonate.The clinical efficacy,symptom severity[Bech-Rafaelsen Mania Scale(BRMS),Positive and Negative Syndrome Scale(PANSS)],quality of life[World Health Organization Quality of Life Scale(WHOQOL-100)],and adverse reactions were compared between the two groups.Results The effective rate of treatment in the study group(95.00%)was higher than that in the control group(77.50%),with statistically significant differences(P<0.05).After 2 months of treatment,BRMS and PANSS scores in both groups decreased,with the study group scoring lower than the control group,showing statistically significant differences(P<0.05).After 2 months of treatment,WHOQOL-100 scores in both groups increased,with the study group scoring higher than the control group,showing statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the study group(10.00%)and the control group(15.00%)(P>0.05).Conclusion Clozapine combined with lithium carbonate in the treatment of BD mania can improve clinical efficacy,alleviate clinical symptoms,enhance quality of life,and avoid exacerbating adverse reactions.