奥氮平联合阿立哌唑在双相情感障碍中的应用效果及对患者生活质量的影响

The Application Effect of Olanzapine Combined with Aripiprazole in Bipolar Disorder and Its Impact on Patients’Quality of Life

目的 分析奥氮平联合阿立哌唑在双相情感障碍中的应用效果及对患者生活质量的影响。方法 选择2020年1月至2022年12月濮阳市精神卫生中心诊治的60例双相情感障碍患者。按照随机数表法分为对照组(30例)、研究组(30例)。对照组应用阿立哌唑治疗,研究组应用阿立哌唑联合奥氮平治疗。对比两组患者贝克拉范森躁狂自评量表(BRMS)评分、认知功能[瑞文标准推理测验(SPM)评分]、生活质量[日常生活能力(ADL)评定量表]、不良反应、临床疗效。结果 治疗前两组BRMS评分比较,差异无统计学意义(P> 0.05);治疗后,研究组BRMS评分低于对照组,差异有统计学意义(P <0.05)。治疗前两组SPM评分比较,差异无统计学意义(P> 0.05);治疗后,研究组SPM评分高于对照组,差异有统计学意义(P <0.05)。治疗前两组ADL评分比较,差异无统计学意义(P> 0.05);治疗后,研究组ADL评分高于对照组,差异有统计学意义(P <0.05)。两组不良反应发生情况比较,差异无统计学意义(P>0.05);研究组治疗有效率(93.33%)高于对照组(70.00%),差异有统计学意义(P <0.05)。结论 奥氮平联合阿立哌唑治疗双相情感障碍患者,可有效改善狂躁程度,提高认知功能和生活质量水平,减少不良反应,增强临床疗效,安全性较好,值得临床治疗应用。

Objective To analyze the application effect of olanzapine combined with aripiprazole in bipolar disorder and its impact on patients’quality of life.Methods Sixty patients with bipolar disorder treated at Puyang Mental Health Center from January 2020 to December 2022 were selected.According to the random number table method,they were divided into a control group(30 cases)and a study group(30 cases).The control group was treated with aripiprazole,while the study group was treated with olanzapine combined with aripiprazole.The Bech-Rafaelsen Mania Scale(BRMS)scores,cognitive function[Raven’s Standard Progressive Matrices(SPM)scores],quality of life[Activities of Daily Living(ADL)scale],adverse reactions,and clinical efficacy were compared between the two groups.Results Before treatment,there was no statistically significant difference in BRMS scores between the two groups(P>0.05).After treatment,the BRMS scores of the study group were lower than those of the control group,with a statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in SPM scores between the two groups(P>0.05).After treatment,the SPM scores of the study group were higher than those of the control group,with a statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in ADL scores between the two groups(P>0.05).After treatment,the ADL scores of the study group were higher than those of the control group,with a statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The effective rate of treatment in the study group(93.33%)was higher than that in the control group(70.00%),with a statistically significant difference(P<0.05).Conclusion The treatment of bipolar disorder with olanzapine combined with aripiprazole can effectively reduce the severity of mania,improve cognitive function and quality of life,reduce adverse reactions,enhance clinical efficacy,and has good safety,making it worthy of clinical application.