解毒疏肝汤联合隔姜灸对老年肝癌介入治疗患者的影响

The Impact of Jiedu Shugan Decoction Combined with Ginger Moxibustion on Elderly Patients with Liver Cancer Undergoing Interventional Therapy

目的 探究解毒疏肝汤联合隔姜灸对老年肝癌介入治疗患者的近期疗效及对血管内皮生长因子(VEGF)、白介素-8(IL-8)、血小板衍生生长因子(PDGF)的影响。方法 选取2020年2月至2023年2月期间在本院进行介入治疗的74例原发性肝郁脾虚型肝癌患者,以随机数表法将其均分为两组,对照组(常规水化、保肝、止吐)及观察组(在常规水化、保肝、止吐的基础上应用解毒疏肝汤联合隔姜灸)各37例,对比两组临床症状(发热、呕吐、肝区疼痛、腹胀、黄疸)改善时间、中医证候积分、肝功能[丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、直接胆红素(DBIL)、总胆红素(TBIL)]、炎症因子[白细胞介素-8(IL-8)、白细胞介素-1(IL-1)、肿瘤坏死因子(TNF-α)]、血管内皮生长因子(VEGF)、血小板衍生生长因子(PDGF)、碱性成纤维细胞生长因子(bFGF)。结果 观察组发热、呕吐、肝区疼痛、腹胀、黄疸改善时间短于对照组,差异有统计学意义(P <0.05)。治疗后,观察组主证、次症、总分低于对照组,差异有统计学意义(P <0.05)。治疗后,观察组ALT、AST、DBIL、TBIL水平低于对照组,差异有统计学意义(P <0.05)。治疗后,观察组IL-8、IL-1、TNF-α水平低于对照组,差异有统计学意义(P <0.05)。治疗后,观察组VEGF、PDGF、bFGF水平低于对照组,差异有统计学意义(P <0.05)。结论 在常规水化、保肝、止吐的基础上实施解毒疏肝汤联合隔姜灸对老年肝癌介入治疗效果显著,可改善患者肝功能、血管内皮功能,降低炎症因子、VEGF、PDGF、bFGF水平。

Objective To explore the short-term efficacy of Jiedu Shugan Decoction combined with ginger moxibustion on elderly patients with liver cancer undergoing interventional therapy and its effects on vascular endothelial growth factor(VEGF),interleukin-8(IL-8),and platelet-derived growth factor(PDGF).Methods A total of 74 patients with primary liver cancer of liver depression and spleen deficiency type who underwent interventional therapy in our hospital from February 2020 to February 2023 were selected.They were randomly divided into two groups using a random number table method:the control group(routine hydration,liver protection,and antiemetic therapy)and the observation group(routine hydration,liver protection,and antiemetic therapy combined with Jiedu Shugan Decoction and ginger moxibustion),with 37 cases in each group.The improvement time of clinical symptoms(fever,vomiting,liver pain,abdominal distension,jaundice),TCM syndrome scores,liver function[alanine aminotransferase(ALT),aspartate aminotransferase(AST),direct bilirubin(DBIL),total bilirubin(TBIL)],inflammatory factors[interleukin-8(IL-8),interleukin-1(IL-1),tumor necrosis factor-α(TNF-α)],vascular endothelial growth factor(VEGF),platelet-derived growth factor(PDGF),and basic fibroblast growth factor(bFGF)were compared between the two groups.Results The improvement time of fever,vomiting,liver pain,abdominal distension,and jaundice in the observation group was shorter than that in the control group,with statistically significant differences(P<0.05).After treatment,the main symptoms,secondary symptoms,and total scores in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of ALT,AST,DBIL,and TBIL in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of IL-8,IL-1,and TNF-αin the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of VEGF,PDGF,and bFGF in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion The implementation of Jiedu Shugan Decoction combined with ginger moxibustion on the basis of routine hydration,liver protection,and antiemetic therapy has a significant effect on elderly patients with liver cancer undergoing interventional therapy.It can improve liver function and vascular endothelial function,reduce the levels of inflammatory factors,VEGF,PDGF,and bFGF.