小儿牛黄清心散治疗热性惊厥患儿的疗效观察

Efficacy Observation of Xiao’er Niuhuang Qingxin Powder in Treating Febrile Seizures in Children

目的 观察小儿牛黄清心散治疗热性惊厥患儿的疗效及对其血糖、乳酸及外周血神经元特异性烯醇化酶(NSE)水平的影响。方法 选择2022年1月至2023年1月商水县人民医院诊治的90例热性惊厥患儿为研究对象,采用抛掷硬币法分为对照组和实验组,两组各45例。对照组给予退热、抗感染、消除痉挛、补充营养及维持水电解质等常规治疗,实验组在常规治疗的基础上加用小儿牛黄清心散治疗。比较两组的临床疗效、惊厥反复次数、发热持续时间、血糖指标、乳酸及血清NSE、脑源性神经营养因子(BDNF)、中枢神经特异蛋白(S-100β)水平。结果 实验组治疗有效率(95.56%)高于对照组(77.78%),差异有统计学意义(P <0.05)。治疗后,实验组反复惊厥次数明显少于对照组,发热持续时间短于对照组,差异有统计学意义(P <0.05)。治疗后,两组血糖水平均降低,且实验组血糖水平低于对照组,两组钠离子水平均升高,且实验组钠离子水平高于对照组,差异有统计学意义(P <0.05)。治疗后,两组乳酸及血清NSE、BDNF、S-100β水平均下降,且实验组水平低于对照组,差异有统计学意义(P <0.05)。治疗期间,两组患儿不良反应发生率对比差异无统计学意义(P> 0.05)。结论 小儿牛黄清心散对儿童热性惊厥有较好的治疗作用,能降低惊厥次数,缩短发热时间,降低血糖、乳酸及血清NES、BDNF、S-100β水平,且安全性良好,值得临床推广。

Objective To observe the efficacy of Xiao’er Niuhuang Qingxin Powder in treating febrile seizures in children and its effects on blood glucose,lactic acid,and peripheral blood neuron-specific enolase(NSE)levels.Methods Ninety children with febrile seizures treated at Shangshui County People’s Hospital from January 2022 to January 2023 were selected as the study subjects.They were divided into a control group and an experimental group using the coin toss method,with 45 cases in each group.The control group received conventional treatment,including antipyretic,anti-infection,spasm elimination,nutritional supplementation,and maintenance of water and electrolyte balance.The experimental group received Xiao’er Niuhuang Qingxin Powder in addition to the conventional treatment.The clinical efficacy,recurrence of seizures,duration of fever,blood glucose levels,lactic acid,serum NSE,brain-derived neurotrophic factor(BDNF),and central nervous system-specific protein(S-100β)levels were compared between the two groups.Results The effective treatment rate in the experimental group(95.56%)was higher than that in the control group(77.78%),with statistically significant differences(P<0.05).After treatment,the recurrence of seizures and duration of fever in the experimental group were significantly lower than those in the control group,with statistically significant differences(P<0.05).After treatment,blood glucose levels in both groups decreased,and the blood glucose levels in the experimental group were lower than those in the control group.Sodium ion levels in both groups increased,and the sodium ion levels in the experimental group were higher than those in the control group,with statistically significant differences(P<0.05).After treatment,lactic acid,serum NSE,BDNF,and S-100βlevels in both groups decreased,and the levels in the experimental group were lower than those in the control group,with statistically significant differences(P<0.05).During the treatment period,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Xiao’er Niuhuang Qingxin Powder has a good therapeutic effect on febrile seizures in children.It can reduce the frequency of seizures,shorten the duration of fever,and lower blood glucose,lactic acid,serum NSE,BDNF,and S-100βlevels.It is safe and worthy of clinical promotion.