阑尾周围炎与溃疡性结肠炎的关联及研究进展

Appendiceal periappendicitis and ulcerative colitis:Relationship and research advances

溃疡性结肠炎(ulcerative colitis,UC)在我国的患病率逐年上升,约高达11.6/10万.此疾病的诊断过程极其漫长且复杂,对我国居民的健康造成了极大的影响.UC通常始发于直肠及乙状结肠,当患有远端结肠炎的患者同时合并了阑尾周围炎(periappendiceal inflammation,PAI),这种情况被认为是UC的“跳跃性病变”.这种现象可能与阑尾作为免疫器官以及其与UC发病机制的免疫相关性有关.PAI合并直肠炎可以为UC的诊断提供便利.然而PAI的发病机理,治疗预后及临床意义,目前尚未达成共识,本文综述了近年来的文献,对PAI进行了综合分析.

The prevalence of ulcerative colitis(UC)has been increasing in China,reaching about 11.6 per 100000.The diagnostic process for this disease is extremely lengthy and complex,significantly impacting the patient’s health.UC typically starts in the rectum and sigmoid colon,and when patients with distal colitis also present with appendiceal periappendicitis,this condition is considered a“skip lesion”of UC.This phenomenon may be related to the appendix’s role as an immune organ and its immunological connection to the pathogenesis of UC.Appendiceal periappendicitis combined with rectal inflammation can facilitate the diagnosis of UC.However,there is still no consensus on the pathogenesis,treatment prognosis,and clinical significance of appendiceal periappendicitis.This paper reviews the recent literature and provides a comprehensive analysis of appendiceal periapp-endicitis.