重组人脑利钠肽联合左西孟旦对射血分数轻度降低的心力衰竭患者左心室功能的影响

Effect of Recombinant Human Brain Natriuretic Peptide Combined with Levosimendan on Left Ventricular Function in Heart Failure Patients with Mildly Reduced Ejection Fraction

目的探究射血分数轻度降低的心力衰竭患者实施重组人脑利钠肽联合左西孟旦对左心室功能的影响。方法选取2023年5月至2024年5月在本院收治的100例射血分数轻度降低的心力衰竭患者,随机分为对照组(重组人脑利钠肽)和观察组(重组人脑利钠肽联合左西孟旦)治疗;比较两组的平均住院天数、住院总费用、住院药费、预后、左心室舒张末期内径(LVEDD)、左心室短袖缩短率(LVFS)、左心室射血分数(LVEF)以及心率(HR)、舒张期室间隔厚度(IVST)、左室后壁厚度(LVPWT)、左心室质量(LVMW)、去甲肾上腺素、醛固酮、血管紧张素Ⅱ与脑利钠肽(BNP)指标。结果观察组住院天数更短(P<0.05),两组住院总费用、住院药费、预后对比差异无统计学意义(P>0.05)。观察组的LVFS、LVEF、HR指标高于对照组,LVEDD指标低于对照组(P<0.05)。观察组的IVST、LVPWT、LVMW均低于对照组(P<0.05)。观察组的血清学指标与BNP均更低(P<0.05)。结论重组人脑利钠肽联合左西孟旦治疗射血分数轻度降低的心力衰竭患者效果显著,不仅可以降低患者的住院费用、缩短住院天数,还有助于减轻家庭的精神负担,具有重要的经济意义。

Objective To investigate the effects of administering recombinant human brain natriuretic peptide in combination with levosimendan on left ventricular function in heart failure patients with mildly reduced ejection fraction.Methods Select 100 heart failure patients with mild decrease in ejection fraction admitted to our hospital from May 2023 to May 2024,and randomly divide them into a control group(recombinant human brain natriuretic peptide)and an observation group.Mean hospital days,total hospital costs,hospital drug costs,prognosis,left ventricular end-diastolic internal diameter(LVEDD),left ventricular short-sleeve shortening(LVFS),left ventricular ejection fraction(LVEF)as well as heart rate(HR),diastolic interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT),left ventricular mass(LVMW),and norepinephrine were compared between the two groups,aldosterone,angiotensin II and BNP indexes.Results The number of hospitalization days was shorter in the observation group(P<0.05),and the difference between the two groups in terms of total hospitalization cost,hospitalization medication cost,and prognosis was not statistically significant when compared(P>0.05).The LVFS,LVEF,HR indexes of the observation group were higher than those of the control group,and the LVEDD indexes were lower than those of the control group(P<0.05).The IVST,LVPWT and LVMW of the observation group were lower than those of the control group(P<0.05).Serological indicators and BNP were lower in the observation group(P<0.05).Conclusions Recombinant human brain natriuretic peptide combined with levosimendan is effective in the treatment of heart failure patients with mildly reduced ejection fraction,which not only reduces the hospitalization cost and shortens the number of days of hospitalization,but also helps to alleviate the mental burden of the family,which is of great economic significance.