比索洛尔联合镇静镇痛治疗阵发性交感神经兴奋的效果

Effect of Bisoprolol Combined with Sedation and Analgesia on the Patients with Paroxysmal Sympathetic Excitation

目的探讨比索洛尔联合镇静镇痛治疗阵发性交感神经兴奋患者的效果。方法选取2021年7月至2023年8月莆田市第一医院接收的96例阵发性交感神经兴奋患者,根据纳入时间分组,其中2021年7月至2022年7月接收的48例患者为对照组,实施常规镇静镇痛治疗;2022年8月至2023年8月接收的48例患者为研究组,实施比索洛尔联合镇静镇痛治疗。对比两组血压、心率、实验室相关指标及不良反应发生情况。结果治疗后研究组患者收缩压、舒张压及心率指标均低于对照组,中枢神经特异性蛋白及神经元特异性烯醇化酶指标均低于对照组(均P<0.05),两组患者不良事件总发生率差异无统计学意义(P>0.05)。结论对阵发性交感神经兴奋患者积极实施比索洛尔联合镇静镇痛治疗,可积极改善患者血压、心率等指标及神经功能,且药物安全性相对较高,加用药物后并未明显增加患者不良反应发生情况。

Objective To investigate the effect of bisoprolol combined sedation and analgesia on the patients with paroxysmal sympathetic excitation.Methods A total of 96 patients with paroxysmal sympathetic excitation received from Putian First Hospital were selected as the subjects.The sample cases were included from July 2021 to August 2023.According to the inclusion time,48 patients received from July 2021 to July 2022 were divided into the control group,and routine sedation and analgesia were administered.From August 2022 to August 2023,48 patients were enrolled as the study group and received bisoprolol combined sedation and analgesia.Blood pressure,heart rate,laboratory-related indexes and the occurrence of adverse reactions were compared between the two groups.Results The indicators of systolic blood pressure,diastolic blood pressure and heart rate of the patients in the study group after treatment were lower than those of the control group,and the indicators of CNS-specific proteins and neuronspecific enolase were lower than those of the control group(all P<0.05),and the difference in the total incidence rate of adverse events between the two groups of patients was not statistically significant(P>0.05).Conclusions Active implementation of bisoprolol combined sedation and analgesia in patients with paroxysmal sympathetic excitation can achieve a more ideal intervention effect,and actively improve blood pressure,heart rate and other indicators and nervous function of patients,and the drug is relatively safe,and the addition of drugs has not significantly increased the occurrence of adverse reactions in patients,which is worthy of application and promotion in clinical treatment.