盐酸氨溴索辅助治疗新生儿感染性肺炎的临床疗效及对患儿动脉血气指标及炎症因子水平的影响

Efficacy of Ambroxol Hydrochloride in Adjuvant Treatment of Neonatal Infectious Pneumonia and its Effect on Arterial Blood Gas and Inflammatory Response

【目的】探讨盐酸氨溴索辅助治疗新生儿感染性肺炎的临床疗效及对患儿动脉血气指标及炎症因子水平的影响。【方法】选取2019年7月至2021年5月本院新生儿科收治的100例感染性肺炎患儿,根据治疗方法不同将其分为观察组和对照组,每组50例。对照组给予常规抗感染治疗,观察组在对照组的基础上给予盐酸氨溴索治疗,对比两组患儿治疗疗效、临床症状体征改善情况及治疗前后动脉血气指标[动脉二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))]、炎症因子[降钙素原(PCT)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)]水平变化。【结果】观察组患儿临床总有效率高于对照组,差异有统计学意义(P<0.05)。观察组吸痰次数少于对照组,平均住院时间、咳喘消失时间、肺部啰音消失时间、退热时间短于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清PCT、TNF-α、CRP水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患儿PaCO_(2)低于治疗前,PaO_(2)高于治疗前,观察组PaO_(2)高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05)。【结论】盐酸氨溴索辅助治疗新生儿感染性肺炎临床效果较好,可有效降低患儿炎症因子水平,改善患儿肺功能,值得临床借鉴。

【Objective】To investigate the clinical efficacy of ambroxol hydrochloride in the adjuvant treatment of neonatal infectious pneumonia and its effect on arterial blood gas and inflammatory response in neonates with infectious pneumonia.【Methods】A total of 100 children with pneumonia treated in the neonatal department of our hospital from July 2019 to May 2021 were selected as the research objects and randomly divided into the observation group and the control group(with 50 cases in each group).The control group was given conventional anti-infective treatment,while the observation group was given ambroxol hydrochloride in addition to conventional anti-infective treatment.The therapeutic efficacy,clinical symptoms and signs,and changes in arterial blood gas indexes[arterial carbon dioxide partial pressure(PaCO_(2)),arterial oxygen partial pressure(PaO_(2))]and inflammatory factors[procalcitonin(PCT),tumor necrosis factor(TNF-α),C-reactive protein(CRP)]before and after treatment were compared between the two groups.【Results】The total clinical effective rate of the observation group was higher than that of the control group(P<0.05).At the end of treatment,the daily sputum suction times of the observation group were significantly less than the control group(P<0.05).The average length of hospitalization in the observation group,the disappearance time of cough and asthma,the disappearance time of pulmonary rales and antipyretic time in the observation group were significantly shorter than those in the control group(all P<0.05).After treatment,PCT,TNF-αand CRP in both groups were lower than those before treatment;And levels of PCT,TNF-αand CRP in the observation group were lower than those in the control group(all P<0.05).At the end of treatment,the levels of PaCO_(2) in the two groups were decreased(all P<0.05),while PaO_(2) was increased(all P<0.05).After treatment,the PaO_(2) level in the observation group was higher,while PaCO_(2) was lower compared to the control group(P<0.05).【Conclusion】Ambroxol hydrochloride adjuvant is effective in the treatment of neonatal infectious pneumonia,which can effectively reduce the levels of inflammatory factors in children and improve their lung function.