西安市灞桥地区中老年人群血清肌酐分布特征及影响因素

Investigation on serum creatinine elevation and influencing factors among middle⁃aged and elderly people in Baqiao area of Xi'an City

目的探讨西安市灞桥中老年人群血清肌酐升高情况及影响因素。方法采用整群抽样的方法,选取西安市灞桥地区7个社区的中老年人群为研究对象,通过问卷调查了解其基本信息,并采集血样,作常规血生化检验,测定血清肌酐水平。采用描述流行病学分析方法分析血清肌酐升高情况,并应用logistic回归模型分析血清肌酐升高的影响因素。结果共纳入2791名中老年人群进行调查,其中男性1423名(50.99%),女性1368名(49.01%);年龄范围40~93岁。血清肌酐水平测定为男性76.54(52.69~102.36)μmol/L,女性69.81(49.32~90.04)μmol/L。482例中老年人检测出血清肌酐升高,升高率为17.27%。其中男性的血清肌酐升高(>106.0μmol/L)率为18.76%,女性的血清肌酐升高(>97.0μmol/L)率为15.72%。多因素logistic回归分析显示,高龄、吸烟、合并高血压、血脂异常、冠心病和高尿酸症是影响中老年人群血清肌酐升高的独立危险因素(P<0.05)。结论中老年人群的血清肌酐水平分布存在性别和年龄差异,且血清肌酐升高受年龄、吸烟以及合并慢性基础疾病情况等诸多因素影响,其中高血压、血脂异常、冠心病和高尿酸症与中老人群肾功能损害紧密相关。

Objective To explore the elevated serum creatinine levels and influencing factors in the middle-aged and elderly population in Baqiao,Xian.Methods Cluster sampling was used to select the middle-aged and elderly population from 7 communities in Baqiao,Xian as the research subjects.Basic infor-mation was collected through questionnaire surveys,and blood samples were collected for routine blood bio-chemistry tests to determine serum creatinine levels.Using descriptive epidemiological analysis methods to ana-lyze the elevation of serum creatinine,and logistic regression models were used to analyze the influencing fac-tors of serum creatinine elevation.Results A total of 2791 middle-aged and elderly individuals were sur-veyed,including 1423 males(50.99%)and 1368 females(49.01%).The age range is 40~93 years old.The serum creatinine levels were measured to be 76.54(52.69~102.36)μmol/L for males and 69.81(49.32~90.04)μmol/L for females.482 middle-aged and elderly individuals were tested for elevated serum creatinine,with an elevation rate of 17.27%.The rate of elevated serum creatinine(>106.0μmol/L)in males was 18.76%,while the rate of elevated serum creatinine(>97.0μmol/L)in females was 15.72%.Multivariate logistic regression analysis showed that advanced age,smoking,concomitant hypertension,dyslipidemia,coronary heart dis-ease,and hyperuricemia were independent risk factors affecting serum creatinine elevation in middle-aged and elderly populations(P<0.05).Conclusion There are gender and age differences in the distribution of serum creatinine levels in middle-aged and elderly populations,and elevated serum creatinine levels are influenced by many factors such as age,smoking,and comorbidities of chronic underlying diseases.Among them,hyperten-sion,dyslipidemia,coronary heart disease,and hyperuricemia are closely related to renal dysfunction in middle-aged and elderly populations.