摘要
Congenital diaphragmatic hernia(CDH)is a major congenital anomaly,resulting from the herniation of abdominal contents into the thoracic cavity,thereby impeding the proper development of the lungs and pulmonary vasculature.CDH severity correlates with a spectrum of pulmonary hypoplasia,pulmonary hypertension(PHT),and cardiac dysfunction,constituting the pathophysiological triad of this complex condition.The accurate diagnosis and effective management of PHT and cardiac dysfunction is pivotal to optimizing patient outcomes.Targeted neonatal echocardiography is instrumental in delivering real-time data crucial for the bespoke,pathophysiology-targeted hemodynamic management of CDH-associated PHT.
基金
JYT holds the endowed Variety,the Children's Charity,and the Stollery Children's Hospital Foundation Pediatric Clinical Research Professorship,with funding support from Women and Children's Health Research Institute and Faculty of Medicine&Dentistry,University of Alberta.
