摘要
免疫检查点抑制剂(ICI)为非小细胞肺癌(NSCLC)治疗的新方法。肿瘤免疫微环境(TIME)由毗邻肿瘤细胞的免疫炎症细胞和免疫活性因子构成,是ICI的重点调节区域,其中T细胞的特点和动态变化与ICI的疗效密切相关。近年来,NSCLC相关TIME中T细胞的生物标志物在如火如荼地探索中。本文对TIME的分型、病理组织及外周血来源T细胞相关生物标志物、影响因素等方面的进展进行综述。
Immune checkpoint inhibitors(ICI)have recently revolutionized the treatment of non-small cell lung cancer(NSCLC).Tumor immune microenvironment(TIME),composed of immune inflammatory cells and related cytokines,is a key region regulated by ICI.The characteristics and dynamic changes of T cells within TIME are closely correlated with the therapeutic effect of ICI.In recent years,efforts have been devoted to exploring the potential biomarkers of T cells in NSCLC.In this review,advances in the phenotypes of TIME,T cell related biomarkers from tumor tissues and peripheral blood,and influencing factors were summarized.
作者
杨银
毕楠
Yang Yin;Bi Nan(Department of Radiation Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2024年第10期971-977,共7页
Chinese Journal of Radiation Oncology
基金
国家自然科学基金(82373216)。
关键词
癌
非小细胞肺
免疫微环境
T细胞
Carcinoma,non-small-cell lung
Tumor immune microenvironment
T cell
