布地奈德雾化吸入联合抗生素序贯治疗支原体肺炎患儿的效果

Effect of Budesonide Aerosol Inhalation Combined with Antibiotic Sequential Therapy on Children with Mycoplasma Pneumonia

目的:探究布地奈德雾化吸入联合抗生素序贯干预对支原体肺炎患儿临床症状及炎性因子的影响。方法:纳入2021年2月—2023年2月我院收治的支原体肺炎患儿96例为研究对象,按随机数字表法设为两组。对照组(n=48)接受抗生素序贯治疗,研究组(n=48)在此基础上给予布地奈德雾化吸入治疗。比较两组临床症状消失时间、炎性因子及免疫指标。结果:研究组高热、咳嗽、喘息消失时间短于对照组(P<0.05);两组治疗后白介素6(IL-6)、白介素2(IL-2)、肿瘤坏死因子α(TNF-α)水平低于治疗前,且研究组低于对照组(P<0.05);两组治疗后免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)水平低于治疗前,且研究组低于对照组(P<0.05)。结论:布地奈德雾化吸入联合抗生素序贯干预可明显改善支原体肺炎患儿临床症状,调节机体炎性因子水平。

Objective:To explore the effect of budesonide aerosol inhalation combined with antibiotic sequential intervention on clinical symptoms and inflammatory factors in children with mycoplasma pneumonia.Methods:A total of 96 children with mycoplasma pneumonia admitted to our hospital from February 2021 to February 2023 were included in the study and divided into two groups according to the random number table method.The control group(n=48)received sequential antibiotic therapy,and the study group(n=48)was treated with budesonide aerosol inhalation on this basis.The disappearance time of clinical symptoms,inflammatory factors and immune indexes were compared between the two groups.Results:The disappearance time of high fever,cough and wheezing in the study group was shorter than that in the control group(P<0.05).After treatment,the levels of interleukin 6(IL-6),interleukin 2(IL-2)and tumor necrosis factorα(TNF-α)in the two groups were lower than those before treatment,and those in the study group were lower than those in the control group(P<0.05).After treatment,immunoglobulin M(IgM),immunoglobulin A(IgA)and immunoglobulin G(IgG)in the two groups were lower than those before treatment,and those in the study group were lower than those in the control group(P<0.05).Conclusion:Budesonide aerosol inhalation combined with antibiotic sequential intervention can significantly improve the clinical symptoms of children with mycoplasma pneumonia and regulate the level of inflammatory factors.