盐酸多奈哌齐联合盐酸川芎嗪治疗中度血管性痴呆的效果

Effect of Donepezil Hydrochloride Combined with Ligustrazine Hydrochloride in the Treatment of Moderate Vascular Dementia

目的:探寻盐酸多奈哌齐与盐酸川芎嗪联合应用对中度血管性痴呆(VD)患者认知功能及神经递质水平的影响。方法:选取2022年4月—2024年4月本院住院治疗的72例中度VD患者为研究对象,按照随机掷硬币法将其分为联用组(n=36)与对照组(n=36)。对照组给予盐酸多奈哌齐治疗,而联用组在对照组的基础上给予盐酸川芎嗪联合治疗,对比两组认知功能、脑血流灌注参数、神经递质水平、心理情况及副作用发生情况。结果:治疗后,联用组HDS、MMSE、BI评分及CVB、CBF、ACh水平高于对照组,MTT、Glu水平低于对照组(P<0.05);两组治疗后副作用发生率比较,差异无统计学意义(P>0.05)。结论:盐酸多奈哌齐与盐酸川芎嗪联合治疗中度VD患者的临床效果佳,对患者认知功能、脑血流、神经递质水平改善明显,且用药安全性高。

Objective:To explore the effect of donepezil hydrochloride combined with ligustrazine hydrochloride on cognitive function and neurotransmitter levels in patients with moderate vascular dementia(VD).Methods:A total of 72 patients with moderate VD who were hospitalized in our hospital from April 2022 to April 2024 were selected as the research objects.They were divided into combined group(n=36)and control group(n=36)according to the random coin toss method.The control group was treated with donepezil hydrochloride,while the combined group was treated with ligustrazine hydrochloride on the basis of the control group.The cognitive function,cerebral blood perfusion parameters,neurotransmitter levels,psychological conditions and side effects were compared between the two groups.Results:After treatment,the scores of HDS,MMSE,BI and the levels of CVB,CBF and ACh in the combined group were higher than those in the control group,and the levels of MTT and Glu were lower than those in the control group(P<0.05).There were no statistical differences in the incidence rates of side effects between both groups after treatment(P<0.05).Conclusion:The clinical effect of donepezil hydrochloride combined with ligustrazine hydrochloride in the treatment of patients with moderate VD is good,which can significantly improve the cognitive function,cerebral blood flow and neurotransmitter level of patients,and the safety of medication is high.