多黏菌素B联合舒巴坦钠治疗多重耐药革兰阴性菌定植或感染患者住院后继发感染的疗效

Efficacy of Polymyxin B Combined with Sulbactam Sodium in the Treatment of Secondary Infections in Patients with Multidrug-resistant Gram-negative Bacterial Colonization or Infection After Hospitalization

目的:探究多黏菌素B联合舒巴坦钠治疗多重耐药革兰阴性菌定植或感染患者住院后继发感染的疗效。方法:选取2020年1月—2024年6月在焦作市第三人民医院及徐州市第七人民医院ICU接受治疗的重症患者186例,按照治疗方法不同将患者随机分为多黏菌素B治疗组和对照组,每组93例。对照组给予注射用舒巴坦钠治疗,多黏菌素B治疗组采用舒巴坦钠联合多黏菌素B治疗。比较两组治疗总有效率、多重耐药革兰阴性菌清除率、住院时间及住院费用。结果:多黏菌素B治疗组治疗总有效率和多重耐药革兰阴性菌清除率分别为98.92%和97.85%,高于对照组的81.72%和73.12%,且多黏菌素B治疗组住院时间及住院费用低于对照组,差异均有统计学意义(P<0.05)。结论:多黏菌素B联合舒巴坦钠治疗可提高多重耐药革兰阴性菌定植或感染患者的效果,提高多重耐药革兰阴性菌清除率,同时缩短患者住院时间,减轻患者经济负担。

Objective:To explore the efficacy of polymyxin B combined with sulbactam sodium in the treatment of secondary infection in patients colonized or infected by multi-drug resistant gram-negative bacteria after hospitalization.Methods:A total of 186 critically ill patients treated in the ICU of the Jiaozuo Third People’s Hospital and Xuzhou Seventh People’s Hospital from January 2020 to June 2024 were selected and randomly divided into polymyxin B treatment group and control group according to different treatment methods,with 93 patients in each group.The control group was treated with sulbactam sodium for injection,and the polymyxin Bgroup was treated with sulbactam sodium combined with polymyxin B.The total effective rate,clearance rate of multi-drug resistant gram-negative bacteria,length of stay and hospitalization cost were compared between the two groups.Results:The total effective rate and clearance rate of multidrug-resistant gram-negative bacteria in polymyxin-E treatment group were 98.92%and 97.85%,respectively,which were higher than 81.72%and 73.12%in the control group,and the hospitalization time and hospitalization cost in polymyxin-E treatment group were lower than those in the control group,with statistical significance(P<0.05).Conclusion:Polymyxin B combined with sulbactam sodium can improve the efficacy of multidrug-resistant gram-negative bacteria colonized or infected patients,increase the clearance rate of multidrug-resistant gram-negative bacteria,shorten the hospital stay of patients,and reduce the economic burden of patients.