多发肺磨玻璃结节的临床管理研究进展

Advances in the clinical management for patients with multiple pulmonary ground-glass nodules

随着CT在肺癌筛查中的广泛应用,肺磨玻璃结节(pulmonary ground-glass nodule, GGN)尤其是多发GGN的检出率越来越高。目前指南对于多发肺结节的治疗仅针对高危结节进行处理,而对于多发高危结节尚无统一指导意见。GGN的主要处理策略是随访和手术切除,对于一些不能切除或不愿手术的患者,可采用立体定向放射治疗、介入消融(如射频消融、微波消融、冷冻消融等)等非手术方法。该文综述了多发肺结节的临床处理策略及疗效评价,旨在为多发肺结节的临床管理提供参考。

With the widespread use of CT scan in lung cancer screening,in clinical practice the detection rate of pulmonary ground-glass nodule(GGN),especially multiple GGNs,has become higher and higher.So far,the guidelines for the treatment of multiple pulmonary nodules mainly focus on the high-risk nodules,while there is no uniform guideline for the management of multiple high-risk GGNs.The main treatment strategies for GGNs include follow-up check and surgical resection.However,for patients who are unable to undergo or refuse to receive surgery,non-surgical therapies such as stereotactic body radiation therapy(SBRT),interventional ablation(such as radiofrequency ablation,microwave ablation,cryoablation,etc.)can be considered.This article reviews the clinical management strategies and therapeutic evaluation of multiple pulmonary nodules,aiming to provide reference for the clinical management of multiple pulmonary nodules.