黄芩素的药理作用及增溶技术研究进展

Progress on Pharmacological Effects and Solubilization Technology of Baicalein

黄芩素是来源于中药黄芩的一种黄酮类有效成分,药理作用广泛,在提高家禽生长性能、抗氧化能力、改善肠道菌群具有良好的应用效果,近年来在兽医学领域得到广泛研究。研究表明黄芩素具有抑菌活性、抑制炎症反应和调节肉鸡肠道微生物平衡等作用。但黄芩素水溶性差,生物利用度不高,大大限制了其临床应用。为提高黄芩素的溶解度,国内外学者开展了大量增溶研究,如共晶、固体分散体、包合物、纳米粒和脂质体等。因此,基于近年来国内外的研究资料,就药理作用和增溶技术两方面对黄芩素的研究现状进行综述,旨在为黄芩素和其他难溶性药物的增溶研究及临床应用提供参考。

Baicalein is a flavonoid active ingredient derived from the traditional Chinese medicine Scutellaria baicalensis,with a wide range of pharmacological effects,and has a good application effect in improving poultry growth performance,antioxidant capacity and improving intestinal flora,and has been widely studied in the field of veterinary medicine in recent years.Studies have shown that baicalein has antibacterial activity,inhibits inflammatory response and regulates the intestinal microbial balance of broilers.However,baicalein has poor water solubility and low bioavailability,which greatly limits its clinical application.In order to improve the solubility of baicalein,scholars at home and abroad have carried out a large number of solubilization studies,such as eutectics,solid dispersions,clathrates,nanoparticles and liposomes.Therefore,based on the research data at home and abroad in recent years,the research status of baicalein in terms of pharmacological effects and solubilization technology is reviewed,aiming to provide reference for the solubilization research and clinical application of baicalein and other poorly soluble drugs.