Theta爆发式磁刺激治疗缺血性脑卒中机制研究进展

Research Progress on the Mechanism of Theta Burst Stimulation in Treating Ischemic Stroke

Theta爆发式磁刺激(theta-burst stimulation,TBS)是重复经颅磁刺激的一种,包括2种刺激模式:具有兴奋作用的间歇性θ短阵脉冲刺激(intermittent TBS,iTBS)和具有抑制作用的持续性θ短阵脉冲刺激(continuous TBS,cTBS)。TBS可应用于卒中后运动障碍、痉挛、认知障碍、失语、忽视等多种卒中后功能障碍,其安全性及有效性已经得到临床验证,但治疗缺血性脑卒中的机制尚未明确。本文简要概述目前TBS临床研究进展及常见有效治疗方案,并总结近年来TBS治疗缺血性脑卒中的机制研究进展,探讨TBS调节卒中后神经元功能及改善卒中结局的可能机制,为临床应用提供参考。

Theta-burst stimulation(TBS) is a form of repetitive transcranial magnetic stimulation,encompassing two stimulation patterns:the excitatory intermittent TBS(iTBS) and the inhibitory continuous TBS(cTBS).TBS can be applied to a variety of post-stroke functional impairments such as motor disorders,spasticity,cognitive impairments,aphasia,and neglect.Its safety and efficacy have been clinically validated,but the mechanism of action in treating ischemic stroke remains unclear.This paper briefly overviews the current progress in TBS clinical research and common effective treatment plans,and summarizes recent studies on the mechanisms of TBS in treating ischemic stroke.It explores potential mechanisms by which TBS regulates neuronal function post-stroke and improves stroke outcomes,providing references for clinical application.