西宁地区急性心肌梗死患者血清PGRN、MCP-1、CDC42与血管病变程度的研究

Correlation among PGRN,MCP-1 and CDC42 in serum and the degree of vascular lesions in patients with acute myocardial infarction in Xining region

目的分析西宁地区急性心肌梗死(AMI)患者血清颗粒蛋白前体(progranulin,PGRN)、单核细胞趋化蛋白1(monocyte chemoattractant protein-1,MCP-1)、细胞分裂周期蛋白42(cell division cycle 42,CDC42)水平,及其与血管病变程度的相关性。方法收集2022年7月—2023年12月在青海省人民医院心血管内科住院的81例AMI患者为病例组,同期80例非冠心病患者为对照组。收集患者一般资料、实验室检查、心脏彩色超声等,酶联免疫吸附法测定各组血清PGRN、MCP-1、CDC42水平;多因素logistic回归分析AMI的危险因素。根据Gensini评分、冠状动脉(冠脉)病变支数及全球急性冠脉事件登记(GRACE)评分将AMI患者进行亚分组。分析各亚组PGRN、MCP-1、CDC42水平与血管病变程度的相关性。结果①与对照组比较,AMI组的血清PGRN、MCP-1水平升高(P<0.05),CDC42水平降低(P<0.05);②不同冠脉狭窄程度的血清PGRN、MCP-1、CDC42均有统计学差异(P<0.05);③不同冠脉血管病变支数的血清PGRN、MCP-1、CDC42均有统计学差异(P<0.05);④不同GRACE评分组的血清PGRN、MCP-1、CDC42均无统计学差异;⑤AMI组中PGRN、MCP-1与Gensini评分、病变支数均呈正相关(P<0.05),与GRACE评分无相关;而AMI组CDC42与Gensini评分、病变支数呈负相关(P<0.05),与GRACE评分无相关;⑥Logistic回归分析示,PGRN、MCP-1是AMI的独立危险因素(P<0.05)。结论血清PGRN、MCP-1与Gensini评分、冠脉病变支数呈正相关,CDC42与Gensini评分、冠脉病变支数呈负相关。PGRN、MCP-1是AMI发生的独立危险因素。

Objective To analyze serum progranulin(PGRN),monocyte chemoattractant protein-1(MCP-1)and cell division cycle 42(CDC42)levels were associated with the degree of vascular disease in patients with acute myocardial infarction(AMI)in Xining area.Methods The 81 patients with AMI hospitalized in the Cardiovascular Department of Qinghai Provincial People's Hospital from July 2022 to December 2023 were collected as the case group,and 80 patients without coronary heart disease were collected as the control group.General data,laboratory examination and heart color ultrasound were collected.Serum PGRN,MCP-1 and CDC42 levels were determined by enzyme-linked immunosorbent assay.Multivariate logistic regression was used to analyze the risk factors of AMI.Patients with AMI were subdivided according to Gensini score,number of coronary lesions,and Global Acute Coronary Event Registry(GRACE)score.The correlation between the levels of PGRN,MCP-1,CDC42 and the degree of vascular disease in each subgroup was analyzed.Results①Compared with the control group,the serum levels of PGRN and MCP-1 in AMI group were increased(P<0.05),and the level of CDC42 was decreased(P<0.05);②There were statistical differences in serum PGRN,MCP-1 and CDC42 in different degrees of coronary artery stenosis(P<0.05);③The serum PGRN,MCP-1 and CDC42 were significantly different in different number of coronary vascular lesions(P<0.05).④There were no significant differences in serum PGRN,MCP-1 and CDC42 among different GRACE groups.⑤In AMI group,PGRN and MCP-1 were positively correlated with Gensini score and number of lesions(P<0.05),but not with GRACE score;In AMI group,CDC42 was negatively correlated with Gensini score and number of lesions(P<0.05),but not with GRACE score.⑥Logistic regression analysis showed that PGRN and MCP-1 were independent risk factors for AMI(P<0.05).Conclusion Serum PGRN and MCP-1 were positively correlated with Gensini score and number of coronary lesions,while CDC42 was negatively correlated with Gensini score and number of coronary lesions.PGRN and MCP-1 were independent risk factors for AMI.