短链脂肪酸与动脉粥样硬化关系的研究进展

Research progress on the relationship between short-chain fatty acids and atherosclerosis

动脉粥样硬化(AS)所导致的心脑血管疾病是一类严重危害人类健康的疾病。近年来研究发现,肠道菌群代谢物短链脂肪酸(SCFAs)通过抑制泡沫细胞活性、调节免疫细胞和炎症、抑制氧化应激在AS发病机制中起到重要作用。SCFAs对AS的具体影响及作用机制已得到越来越多的关注。本文就SCFAs的一般特性、SCFAs在AS发展中的作用、通过干预SCFAs防治AS的最新研究进展作一综述。

Ardio-cerebrovascular diseases caused by atherosclerosis(AS)are a class of diseases that seriously harm human health.Recent studies have found that intestinal flora metabolites short-chain fatty acids(SCFAs)play an important role in the pathogenesis of AS by inhibiting foam cell activity,regulating immune cells and inflammation,and inhibiting oxidative stress.More and more attention has been paid to the specific effects and mechanisms of SCFAs on AS.In this paper,the general characteristics of SCFAs,the role of SCFAs in the development of AS,and the latest research progress on the prevention and treatment of AS through SCFAs intervention are reviewed.