无创呼吸机联合布地格福对AECOPD患者炎症指标及肺功能的影响

Effects of noninvasive ventilator combined with budigofort on inflammatory indexes and lung function in patients with AECOPD

目的探究无创呼吸机联合布地格福对慢阻肺急性加重期(AECOPD)患者炎症指标及肺功能的影响。方法随机将廉江市人民医院2021年2月-2023年12月收治的AECOPD患者90例分为两组,每组各45例。对照组采用无创呼吸机治疗,观察组在此基础上加用布地格福治疗。对比两组治疗前后的炎症指标、肺功能、不良反应。结果治疗1周,两组的C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平比治疗前低,且观察组更低,两组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC均升高,观察组更高(P<0.05)。两组不良反应对比,无统计学差异(P>0.05)。结论无创呼吸机联合布地格福可减轻AECOPD患者炎症反应,提高其肺功能,且不增加不良反应。

Objective To explore the effects of non-invasive ventilator combined with budigovir on inflammatory indexes and lung function in patients with acute COPD exacerbation(AECOPD).Methods 90 patients with AECOPD admitted to our hospital from February 2021 to December 2023 were randomly divided into two groups,45 cases in each group.The control group was treated with noninvasive ventilator,and the observation group was treated with budigafol.The inflammatory indexes,lung function and adverse reactions of the two groups were compared before and after treatment.Results After 1 week of treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in two groups were lower than before treatment,and the levels in observation group were lower,and the forced expiratory volume(FEV1),forced vital capacity(FVC)and FEV1/FVC in two groups were increased,and the levels in observation group were higher(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Non-invasive ventilator combined with budigafol can reduce inflammation and improve lung function in patients with AECOPD without increasing adverse reactions.