摘要
A rhodium(Ⅲ)-catalyzed hydrosilylation/cyclization reaction of cyclohexadienone-tetheredα,β-unsaturated aldehydes(1,6-dienes)with triethylsilane is described,providing a series of cishydrobenzofurans,cis-hydroindoles,and cishydroindenes bearing silyl enol ether in good to excellent yields and excellent stereoselectivities.Additionally,the versatility of this method was demonstrated through a gram-scale experiment and various downstream transformations,highlighting its utility.
基金
financial support from the National Key R&D Program of China(No.2022YFF1202600)
the National Natural Science Foundation of China(Nos.22001172,22071155,and22371188)
the Science and Technology Commission of Shanghai Municipality(Nos.20XD1403600 and 20400750300)
the Shanghai Municipal Education Commission(No.2019-01-07-00-10-E00072)
the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-202004)
the Shanghai Municipal Health Commission/Shanghai Municipal Administration of Traditional Chinese Medicine[No.ZY(2021-2023)-0501]
Organizational Key R&D Program of SHUTCM(No.2023YZZ01)。