摘要
Unlike regenerative-competent species that possess a remarkable intrinsic capacity to replenish lost neurons and restore neurocircuits spontaneously,the central nervous system in adult mammals lacks the ability to compensate for the neuronal loss caused by neurodegenerative diseases or traumatic injuries resulting in permanent loss of functionality.Inspired by earlier discoveries that radial glia or astrocytes isolated from the postnatal cortex can generate neurons.
基金
supported by National Institutes of Health grants R01 EY024986 and R01 EY028921,an unrestricted challenge grant from Research to Prevent Blindness
the New York Eye and Ear Infirmary Foundation
The Harold W.McGraw,Jr.Family Foundation for Vision Research(to BC)。
