摘要
Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least asymmetrically.The disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum.
基金
partially supported by the Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research(KAKENHI,Grant numbers 23H02865[to KK],23K14927[to CA])
the Brain/MINDS Beyond program of the Japan Agency for Medical Research and Development(Grant Number JP19dm0307101[to KK])。
