药物性肝损伤的临床新进展

Recent Clinical Advances in Drug-Induced Liver Injury

药物性肝损伤(Drug Induced Liver Injury,DILI)是指由药物本身或其代谢物导致的肝脏损伤,在我国常由于中草药、膳食补充剂、美容塑形药物以及抗结核药物等引起,是临床引起急性肝衰竭的重要因素之一。本文主要对药物性肝损伤发病机制和生物标志物进行综述,以期提高临床用药安全性。

Drug-induced liver injury(DILI)refers to liver damage caused by a drug or its metabolites.In China,it is often attributed to traditional Chinese herbal medicines,dietary supplements,cosmetic and slimming drugs,and anti-tuberculosis medications.DILI is also a significant clinical cause of acute liver failure.This paper provides a comprehensive review of the mechanisms and biomarkers of DILI,aiming to enhance the safety of clinical drug use.