帕金森病合并重症肌无力1例

A case report of Parkinson disease complicated with myasthenia gravis

报道1例80岁帕金森病(Parkinson disease,PD)合并重症肌无力(myasthenia gravis,MG)男性患者,6年前因运动迟缓、静止性震颤外院诊断PD,口服多巴丝肼及吡贝地尔缓释片治疗。1月前因出现左眼睑下垂入院,新斯的明试验阳性,检测抗乙酰胆碱受体(acetylcholine receptor,AChR)抗体阳性,符合MG诊断标准,应用糖皮质激素及溴吡斯的明治疗MG症状显著改善,但PD症状有所加重,在MG改善后停用溴吡斯的明,加用多巴丝肼后患者PD症状改善,随访3年患者病情控制平稳。PD合并MG较为罕见,结合文献复习阐述其可能的共病机制及治疗策略,以期提高临床医生对此合并症的全面认识与诊治能力。

This case report described an 80-year-old male patient with Parkinson disease(PD)complicated with myasthenia gravis(MG).Six years ago,the patient was diagnosed with PD based on the motor symptoms including bradykinesia and static tremor and treated with levodopa-benserazide and piribedil sustained-release tablets.He was admitted to the hospital due to left eyelid ptosis one month ago.The result of Neostigmine test was positive and anti acetylcholine receptor(AChR)antibodies of serum was positive,which met the diagnostic criteria for myasthenia gravis(MG).The symptom of MG improved significantly after treatment with glucocorticoid and pyridostigmine but the PD symptoms worsened.The symptoms of PD were improved after withdrawal of pyridostigmine and use of the levodopa benserazide and his condition maintained stable at 3 years of follow-up.The PD complicated with MG was fairly rare.We also reviewed the literature on the possible comorbidity mechanism and treatment strategies to improve the comprehensive understanding and ability of diagnosis and treatment of clinicians.