法尼醇X受体在肠道疾病中的研究进展

Research progress of farnesoid X receptor in intestinal diseases

法尼醇X受体(farnesoid X receptor,FXR)是胆汁酸的受体之一,同时也是一种依赖配体转录因子,其在调控机体的胆汁酸稳态和免疫反应方面发挥着关键作用。FXR激活异常可使胆汁酸代谢紊乱和炎症途径失调,并可引发多种肠道疾病。本文概述了FXR在肠道疾病发病中的机制及FXR激动剂起到的作用,以期为这些疾病的临床诊治提供参考依据。

Farnesoid X receptor(FXR),one of the bile acid receptors and a ligand-dependent transcription factor,plays an important role in regulating bile acid homeostasis and immune responses.Abnormal activation of FXR expression can lead to disturbance of bile acid metabolism and dysregulation of inflammatory pathways,inducing a variety of intestinal diseases.In this paper,we briefly reviewed the possible roles of FXR in pathogenesis of intestinal diseases and the role played by FXR agonists,with the aim of providing a reference for clinical management.