口腔菌群:口腔鳞状细胞癌诊断和预后的生物标志物

Oral microbiota: a biomarker for the diagnosis and prognosis of oral squamous cell carcinoma

口腔菌群在口腔鳞状细胞癌(OSCC)的发生、发展及转归过程中始终呈动态变化, 二者相互促进, 相辅相成, 密不可分;口腔菌群在健康者、OSCC癌前病变者、OSCC患者中存在差异, 可以作为OSCC癌前病变或OSCC诊断的标志物;口腔菌群的基线水平以及治疗后的变化在不同患者中也存在差异, 可作为OSCC预后的生物标志物;口腔菌群的调节还可以作为一种微生物疗法, 加入到现有标准疗法中, 进一步改善OSCC患者的预后。

The oral microbiota has been dynamically changing in the process of formation,development and prognosis of oral squamous cell carcinoma(OSCC),and the two promote and complement each other inseparably.Oral microbiota is different in healthy people,patients with precancerous lesions of OSCC,and patients with OSCC,which means it can be used as a biomarker for the diagnosis of precancerous lesions of OSCC or OSCC.In addition,there are differences in the levels of oral microbiota both at baseline and after treatment among different OSCC patients,which can be used as a prognostic biomarker for OSCC.Furthermore,the modulation of oral microbiota can be used as a microbial therapy to improve the prognosis of OSCC patients by being added to the existing standard therapies.