寻常型银屑病患者外周血Adropin和P1NP表达及临床意义

Expression and clinical significance of Adropin and P1NP in serum of patients with psoriasis vulgaris

目的探讨寻常型银屑病(PV)患者血清Adropin和Ⅰ型胶原氨基端延长肽(P1NP)表达及其临床意义。方法选取2019年1月-2021年1月我院诊治的70例PV患者为PV组,根据银屑病皮损面积和严重程度评分(PASI),将PV组分为轻中度组(PASI评分≤12分,n=40)和重度组(PASI评分>12分,n=30),以同期健康体检的40例健康者为对照组。酶联免疫吸附实验检测血清Adropin、P1NP及肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-8水平。相关性分析采用Pearson相关性分析。多因素Logistic回归分析影响PV严重程度的因素。受试者工作特征曲线(ROC)分析各指标对PV严重程度的评估价值。结果PV组血清Adropin、P1NP水平低于对照组,差异有统计学意义(t=13.828,15.993,均P<0.05)。重度组PV患者血清Adropin、P1NP水平低于轻中度组,而超敏C反应蛋白(hs-CRP)、TNF-α、IL-8水平高于轻中度组,差异有统计学意义(均P<0.05)。PV组患者血清Adropin、P1NP水平与hs-CRP、TNF-α、IL-8均呈显著负相关(均P<0.05)。血清Adropin、P1NP是影响重度PV发生的独立保护因素,hs-CRP是危险因素。Adropin、P1NP、hs-CRP 3项联合对重度PV诊断的曲线下面积为0.933(0.866~0.967),高于单一指标0.853(0.806~0.899)、0.817(0.743~0.851)、0.848(0.793~0.881),差异有统计学意义(Z=5.864、5.072、5.776,均P<0.05)。结论PV患者血清Adropin、P1NP水平降低,两者与PV病情严重程度有关,Adropin、P1NP、hs-CRP联合检测有助于评估PV疾病严重程度。

Objective To study the serum expression of Adropin and type I collagen amino-terminal lengthening peptide(P1NP)in patients with psoriasis vulgaris(PV)and their clinical significance.Methods 70 patients with PV treated in our hospital from January 2019 to January 2021 were selected as PV group.According to the Psoriasis Lesion Area and Severity Scale(PASI),PV group was divided into mild to moderate group(PASI score≤12 points,n=40)and severe group(PASI score>12 points,n=30),and 40 healthy persons in the same period were selected as control group.Enzyme-linked immunosorbent assay was used to detect the serum level of Adropin,P1NP and tumor necrosis factor-α(TNF-α),interleukin(IL)-8.The correlation was conducted by Pearson correlation analysis.Multivariate logistic regression analysis was used to analyze the factors affecting the severity of PV.The ROC curve analyzes the evaluation value of each index on the severity of PV.Results The serum expression of Adropin,P1NP in PV group were significantly lower than that in the control group(t=13.828,15.993,P<0.05).Serum level of Adropin and P1NP in severe group were significantly lower than those in mild and moderate group,while hs-CRP,TNF-α,IL-8 were significantly higher than those in mild and moderate group(P<0.05).The levels of Adropin,P1NP were negatively correlated with hs-CRP,TNF-α,IL-8 in patients with PV(P<0.05).Serum Adropin and P1NP were independent protective factors that affect the occurrence of severe PV,while hs-CRP was a risk factor.The area under the curve of Adropin,P1NP,and hs-CRP combined for the diagnosis of severe PV was 0.933(0.866~0.967),which was higher than the single indicator of 0.853(0.806~0.899),0.817(0.743~0.851),and 0.848(0.793~0.881)(Z=5.864,5.072,5.776,all P<0.05).Conclusion The levels of Adropin and P1NP in peripheral blood of patients with PV are decreased,which are related to the severity of PV.The combined detection of Adropin,P1NP and hs-CRP is helpful to evaluate the severity of PV.