丹参注射液对肺尘埃沉着病合并肺心病患者的临床疗效、右心功能及血气分析的影响

Effect of Danshen Injection on the clinical efficacy,right heart function and blood gas analysis of pneumoconiosis complicated with pulmonary heart disease

目的探讨丹参注射液对肺尘埃沉着病合并肺心病患者的临床效果。方法选取2020年1月至2021年12月赣州市第五人民医院收治的60例肺尘埃沉着病合并肺心病患者作为研究对象,按照随机数字表法分为常规组(n=30)与丹参组(n=30)。常规组采用常规对症治疗,丹参组在常规组的基础上加用丹参注射液进行治疗,两组患者均连续治疗两周。分别于治疗前后对两组患者进行心脏彩色多普勒超声检查,比较两组患者右心腔的大小和右心室Tei指数,并比较两组患者的临床疗效和血气分析。结果丹参组的临床治疗总有效率、动脉血氧分压和血氧饱和度高于常规组,丹参组的右心腔大小和右心室Tei指数低于常规组,丹参组的动脉血二氧化碳分压低于常规组,差异有统计学意义(P<0.05)。结论丹参注射液能够有效改善肺尘埃沉着病合并肺心病患者的临床症状、血气指标及右心功能。

Objective To investigate the clinical effect of Danshen Injection on pneumoconiosis complicated with pulmonary heart disease.Methods A total of 60 patients with pneumoconiosis combined with pulmonary heart disease admitted to the Fifth People's Hospital of Ganzhou from January 2020 to December 2021 were selected as the study objects,and they were divided into the conventional group(n=30)and the Danshen group(n=30)according to random number table method.The conventional group was treated with conventional symptomatic treatment,and the Danshen group was treated with Danshen Injection on the basis of the conventional group.Both the two groups were treated continuously for two weeks.Cardiac color Doppler ultrasound was performed before and after treatment to compare the size of the right heart cavity and the Tei index of the right ventricle between the two groups,the clinical efficacy and blood gas analysis were compared between the two groups.Results The total effective rate,partial arterial oxygen pressure,blood oxygen saturation percentage in Danshen group were higher than those in the conventional group,right ventricular cavity size and right ventricular Tei index in Danshen group were lower than those in the conventional group,and the partial pressure of carbon dioxide in arterial blood in the Danshen group was lower than that in the conventional group,the differences were statistically significant(P<0.05).Conclusion Danshen injection can effectively improve the clinical symptoms,blood gas index and right heart function in patients with pneumoconiosis complicated with pulmonary heart disease.