子宫内膜癌患者血微小RNA-133b、可溶性fms样酪氨酸激酶1水平与预后的相关性研究

Correlation between blood microRNA-133b and soluble FMS-like tyrosine kinase 1 levels and prognosis in patients with endometrial cancer

目的研究子宫内膜癌患者血微小RNA-133b(miR-133b)、可溶性fms样酪氨酸激酶1(sFLT1)水平与预后的相关性。方法前瞻性选取2015年1月至2016年1月在该院妇科就诊的122例子宫内膜癌患者的临床资料,根据子宫内膜癌患者5年预后情况将其分为生存组(n=58)和死亡组(n=64),比较两组患者的miR-133b和sFLT1水平。采用Cox回归分析miR-133b和sFLT1与子宫内膜癌患者预后的关系。结果生存组miR-133b和sFLT1水平均高于死亡组,差异有统计学意义(P<0.05)。miR-133b低水平组的中位生存时间短于miR-133b高水平组,差异有统计学意义(P<0.05);sFLT1低水平组的中位生存时间短于sFLT1高水平组,差异有统计学意义(P<0.05)。国际妇产科联合会(FIGO)分期Ⅲ~Ⅳ和淋巴结转移是子宫内膜癌预后的独立危险因素(P<0.05),病理G1~G2级、高水平miR-133b和高水平sFLT1是子宫内膜癌预后的独立保护因素(P<0.05)。结论子宫内膜癌患者的miR-133b和sFLT1水平低均与疾病进展有关,是预后的独立风险因素。

Objective To study the relationship between blood microRNA-133b(miR-133b)and soluble fms-like tyrosine kinase 1(sFLT1)levels with the prognosis in the patients with endometrial cancer.Methods A total of 122 patients with endometrial cancer visited in the gynecology department of this hospital from January 2015 to January 2016 were prospectively selected as the study subjects,and divided into the survival group(n=58)and death group(n=64)according to the 5-year prognosis of the patients with endometrial cancer.The miR-133b and sFLT1 levels were compared between the two groups.The COX regression was used to analyze the relationship between miR-133b and sFLT1 with the prognosis of the patients with endometrial cancer.Results The levels of miR-133b and sFLT1 in the survival group were higher than those in the death group,and the differences were statistically significant(P<0.05).The median survival time in the miR-133b low-level group was shorter than that in the miR-133b high level group,and the difference was statistically significant(P<0.05).The median survival time of the sFLT1 low level group was shoeter than that in the sFLT1 high level group,and the difference was statistically significant(P<0.05).The FIGO stageⅢ-Ⅳand lymph node metastasis were the independent risk factors for the prognosis of endometrial cancer(P<0.05),and the pathological G1-G2,high level of miR-133b and sFLT1 were the independent protective factors for the prognosis of endometrial cancer(P<0.05).Conclusion The miR-133b and sFLT1 low levels in the patients with endometrial cancer are associated with the disease progression,and both are the independent risk factors of prognosis.