艾灸整复生物钟介导的巨噬细胞昼夜节律治疗RA免疫衰老的潜在机制研究进展

Research progress on potential mechanism of moxibustion restoring circadian rhythm mediated macrophage circadian rhythm in treatment of RA immunosenescence

类风湿性关节炎(RA)是以慢性滑膜炎症为特征的自身免疫性疾病。艾灸治疗能明显改善RA免疫紊乱,减轻滑膜炎症,但其作用机制有待进一步深入。衰老是诱使RA发生、发展的关键因素,巨噬细胞作为免疫系统监测衰老的关键哨点,在RA的发病过程中发挥了重要作用。生物钟主导机体的昼夜节律,调控着多种蛋白表达和细胞功能,广泛参与多种疾病的生理、病理过程。生物钟参与巨噬细胞衰老,具有调节免疫紊乱的作用,而在影响RA发生、发展的机制中,巨噬细胞衰老作为重要的突破点已受到越来越多的关注。该文主要从生物钟参与巨噬细胞衰老角度出发,阐明RA可能的发病机制并分析艾灸通过调控生物钟参与巨噬细胞衰老,从而治疗RA的可行性。

Rheumatoid arthritis(RA)is an autoimmune disease characterized by chronic synovial inflammation.Moxibustion treatment can significantly improve RA immune disorders and reduce synovial inflammation,but its mechanism of action needs to be further deepened.Senescence is a key factor that induces the occurrence and development of RA,and macrophages,as the key sentinel sites of the immune system to monitor aging,play an important role in the onset process of RA.The circadian clock dominates the circadian rhythm of the body,regulates the expression of a variety of proteins and cell functions,and is widely involved in the physiological and pathological processes of a variety of diseases.The circadian clock is involved in macrophage senescence and has the effect of regulating immune disorders.Among the mechanisms affecting the occurrence and development of RA,macrophage senescence has received more and more attentions as an important breakthrough point.Therefore,this article mainly elucidates the possible pathogenesis of RA from the perspective of the involvem ent of the biological clock in macrophage senescence and analyzes the feasibility of moxibustion in the treatment of RA by regulating the biological clock and participating in macrophage senescence.