社区获得性肺炎患者血清HBD-1、SAA、sIL-2R水平变化及指导病情分级的意义

Changes in serum HBD-1,SAA,and sIL-2R levels in patients with community-acquired pneumonia and the significance of guiding disease classification

目的检测社区获得性肺炎(CAP)患者血清防御素-1(HBD-1)、淀粉样蛋白A(SAA)、可溶性白细胞介素-2受体(sIL-2R)水平变化,并分析其对病情分级的指导意义。方法选取2021年7月至2023年8月在该院收治的85例CAP患者(CAP组),根据肺炎严重度指数(PSI)将其分为低风险组(34例)、中风险组(41例)和高风险组(10例),另取85例健康成人作为对照组。比较CAP组和对照组血清HBD-1、SAA和sIL-2R水平,比较PSI不同风险分组血清HBD-1、SAA和sIL-2R水平;采用受试者操作特征(ROC)曲线分析HBD-1、SAA、sIL-2R水平对CAP患者的诊断价值;采用Spearman相关性分析CAP患者PSI值和血清HBD-1、SAA、sIL-2R水平之间的关系。结果CAP患者血清HBD-1、SAA和sIL-2R水平均高于对照组,其中PSI评分不同分组血清HBD-1、SAA和sIL-2R水平由高到低为高风险组>中风险组>低风险组,差异有统计学意义(P<0.05)。ROC曲线分析结果显示,血清HBD-1[曲线下面积(AUC)=0.739]、SAA(AUC=0.773)、sIL-2R(AUC=0.730)水平对CAP患者具有良好的诊断价值(P<0.05)。Spearman相关性分析结果显示,血清HBD-1水平[相关系数(r)=0.304]、SAA(r=0.498)和sIL-2R(r=0.435)水平与PSI评分呈正相关(P<0.05)。结论血清HBD-1、SAA、sIL-2R水平对CAP患者的病情分级具有较好的指导意义。

Objective To measure the levels of serum human beta-defensin-1(HBD-1),serum amyloid A(SAA),and soluble interleukin-2 receptor(sIL-2R)in patients with community-acquired pneumonia(CAP)and to analyze their significance in guiding disease severity classification.Methods From July 2021 to August 2023,85 CAP patients(the CAP group)treated at the hospital were selected and categorized into the low-risk(34 cases),the moderate-risk(41 cases),and the high-risk(10 cases)groups based on the Pneumonia Severity Index(PSI).Another 85 healthy adults were included as a control group.The levels of serum HBD-1,SAA,and sIL-2R in the CAP group and the control group were compared,as well as among different PSI risk categories.Receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic value of HBD-1,SAA,and sIL-2R levels for CAP patients.Spearman correlation analysis was applied to assess the relationship between PSI scores and the levels of s erum HBD-1,SAA,and sIL-2R in CAP patients.Results Levels of serum HBD-1,SAA,and sIL-2R in the CAP patients were higher than those in the control group.Among the PSI categories,levels decreased from the high-risk to low-risk groups with significant differences(P<0.05).ROC analysis indicated that serum levels of HBD-1(AUC=0.739),SAA(AUC=0.773),and sIL-2R(AUC=0.730)had good diagnostic value for the CAP patients(P<0.05).Spearman correlation analysis showed positive correlations between PSI scores and levels of HBD-1[correlation coefficient(r)=0.304],SAA(r=0.498),and sIL-2R(r=0.435)(P<0.05).Conclusion Serum levels of HBD-1,SAA,and sIL-2R have significant guidance value in the severity classification of CAP patients.