哮喘患儿血清干扰素-γ白三烯B4白细胞介素-6水平对疾病预后的预测价值

Predictive value of serum IFN-γ,LTB4,and IL-6 levels on disease prognosis in children with asthma

目的探究哮喘患儿血清干扰素-γ(IFN-γ)、白三烯B4(LTB4)、白细胞介素-6(IL-6)水平对疾病预后的预测价值。方法选取2022年3月至2023年3月我院收治的支气管哮喘急性发作期患者80例为研究对象,治疗4周,根据哮喘控制测试对患儿病情控制情况进行评估,分为未完全控制组34例,完全控制组46例。比较2组治疗前、治疗4周后血清IFN-γ、LTB4、IL-6及血气指标[动脉血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))],分析治疗4周后其与血气功能的相关性及联合预测价值。结果治疗4周后未完全控制组血清IFN-γ、LTB4、IL-6水平高于完全控制组(P<0.05);治疗4周后未完全控制组PaO_(2)水平低于完全控制组,PaCO_(2)水平高于完全控制组(P<0.05);治疗4周后哮喘患者血清IFN-γ、LTB4、IL-6水平与PaO_(2)呈负相关,与PaCO_(2)呈正相关(P<0.05);治疗4周后血清IFN-γ、LTB4、IL-6水平联合检测预测哮喘患儿患者预后情况的曲线下面积(AUC)为0.742(P<0.05)。结论血清IFN-γ、LTB4、IL-6水平与哮喘发病密切相关,可作为临床判断患者病情、评估预后转归的有效指标。

Objective To investigate the prognostic value of serum interferon-γ(IFN-γ),leukotriene B4(LTB4),and interleukin-6(IL-6)levels in children with asthma.Methods A total of 80 patients with acute attacks of bronchial asthma admitted to our hospital from March 2022 to March 2023 were selected as the study objects.The patients were treated for 4 weeks and followed up for 3 months.According to the asthma control test,the disease control status of the children was evaluated,and they were divided into 34 cases in the incomplete control group and 46 cases in the complete control group.Serum IFN-γ,LTB4,IL-6,and blood gas indexes[arterial partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO_(2))]were compared between the two groups before and after 4 weeks of treatment,and their correlation and joint predictive value of blood gas function were analyzed after 4 weeks of treatment.Results After 4 weeks of treatment,the serum levels of IFN-γ,LTB4,and IL-6 in incomplete control group were higher than those in the complete control group(P<0.05).After 4 weeks of treatment,PaO_(2)level in the incomplete control group was lower than that in the complete control group,and the PaCO_(2)level was higher than that in the complete control group(P<0.05).After 4 weeks of treatment,serum IFN-γ,LTB4,and IL-6 levels were negatively correlated with PaO_(2),but positively correlated with PaCO_(2)(P<0.05).After 4 weeks of treatment,the AUC of serum IFN-γ,LTB4,and IL-6 levels combined to predict the prognosis of children with asthma was 0.742(P<0.05).Conclusion Serum IFN-γ,LTB4,and IL-6 levels are closely related to the onset of asthma,which can be used as an effective index to judge the patients′condition and evaluate the prognosis.