基于数据挖掘分析中医药治疗血精的用药规律

Analysis of the medicine rule in treating hemospermia with traditional Chinese medicine based on data mining

目的基于数据挖掘技术总结中医药治疗血精的用药规律。方法检索中国知网、万方数据知识服务平台和维普网3个中文数据库2002年1月至2023年12月有关中医治疗血精的文献,按照纳入及排除标准筛选文献,对纳入的文献进行资料收集和录入。对中药名称进行标准化处理,并利用频率分布、性味归经、关联规则、聚类分析和因子分析等方法对数据进行全面分析。结果共纳入112首方剂,获得198味中药,用药频次总计为1418次,使用频次较高的中药包括牡丹皮、生地黄、黄柏、墨旱莲、甘草等。高频药物多为清热药、补虚药、止血药;药性以寒性为主;药味以甘、苦味为主;归经以肝、肾、心经为主。关联分析获得7组核心药物组合,聚类分析得出5个新的方剂组合,因子分析得到8个公因子,累积方差贡献率为65.67%。结论中医药治疗血精以补虚、清热、止血为主,攻补兼施,标本同治。

Objective To summarize the medicine rule in treating hemospermia with traditional Chinese medicine based on data mining technology.Methods Literature on traditional Chinese medicine treatment of hemospermia was retrieved from three Chinese databases:CNKI,Wanfang Data,and VIP from January 2002 to December 2023.References were screened according to inclusion and exclusion criteria,data were collected and entered for the included references,and traditional Chinese medicine names were standardized.Methods such as frequency distribution,nature,flavour,and channel tropism,association rules,cluster analysis,and factor analysis were used to conduct a comprehensive analysis of the data.Results A total of 112 first prescriptions were included,198 traditional Chinese medicine were obtained,and the frequency of administration was 1418 times.The most frequently used traditional Chinese medicines included Moutan Cortex,raw Rehmanniae Radix,Phellodendri Chinensis Cortex,Ecliptae Herba,Glycyrrhizae Radix Et Rhizoma,and so on.The high-frequency drugs were mainly clearing heat drugs,tonifying deficiency drugs,and hemostatic drugs.The drug matures were mainly cold.The drug flavours were mainly sweet and bitter.The channel tropisms were mainly liver,kidney,and heart channels.A total of seven groups of core drug combinations were obtained by association analysis,five new prescription combinations were obtained by cluster analysis,and eight common factors were obtained by factor analysis.The cumulative variance contribution rate was 65.67%.Conclusion The main treatment of hemospermia with traditional Chinese medicine is tonifying deficiency,clearing heat and stopping bleeding,reinforcement and elimination in combination,and treating both manifestation and root cause of disease.