血清肿瘤标志物CA125、CA199、CA72-4、CEA联合检测在胃肠道肿瘤中的应用价值

Application value of combined detection of serum tumor markers CA125,CA199,CA72-4 and CEA in gastrointestinal tumors

目的:探讨血清肿瘤标志物糖类抗原125(CA125)、糖类抗原199(CA199)、糖类抗原72-4(CA72-4)及癌胚抗原(CEA)联合检测在胃肠道肿瘤中的应用价值。方法:随机选取158例胃肠道肿瘤病人(观察组)与46例胃肠道良性病变病人(对照组)的临床资料进行回顾性分析,检测2组CA125、CA199、CA72-4、CEA并进行统计学分析,评估CA125、CA199、CA72-4、CEA在胃肠道肿瘤病人中的应用价值。结果:观察组CA125、CA199、CA72-4、CEA水平均明显高于对照组(P<0.01);在不同病理分化类型的胃肠道肿瘤中CA125、CA199、CA72-4、CEA水平由低到高为高分化腺癌<中分化腺癌<低分化腺癌,差异有统计学意义(P<0.05~P<0.01);有淋巴结转移的胃肠道肿瘤CA125、CA199、CA72-4、CEA水平高于无淋巴结转移(P<0.05~P<0.01);CA125、CA199、CA72-4、CEA联合检测诊断胃肠道肿瘤的AUC均高于上述四项指标单独检测诊断,差异有统计学意义(P<0.01)。结论:对胃肠道肿瘤病人进行CA125、CA199、CA72-4、CEA联合检测,可为临床医生诊断胃肠道肿瘤提供依据,同时也能较为准确地分析其病情,有利于了解肿瘤的病理分化和有无淋巴结转移。

Objective:To explore the application value of combined detection of serum tumor markers carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199),carbohydrate antigen 72-4(CA72-4),and carcinoembryonic antigen(CEA)in gastrointestinal tumors.Methods:Clinical data of 158 patients with gastrointestinal tumors(observation group)and 46 patients with benign gastrointestinal lesions(control group)were randomly selected for retrospective analysis.CA125,CA199,CA72-4,and CEA were detected in the two groups and statistically analyzed to evaluate the application value of CA125,CA199,CA72-4,and CEA in patients with gastrointestinal tumors.Results:The levels of CA125,CA199,CA72-4,and CEA in the observation group were significantly higher than those in the control group(P<0.01).The levels of CA125,CA199,CA72-4,and CEA in gastrointestinal tumors of different pathological differentiation types were as follows:well differentiated adenocarcinoma<moderately differentiated adenocarcinoma<poorly differentiated adenocarcinoma,with statistically significant differences(P<0.05 to P<0.01).The levels of CA125,CA199,CA72-4,and CEA in gastrointestinal tumors with lymph node metastasis were higher than those without lymph node metastasis(P<0.05 to P<0.01).The AUC of the ROC curve for the combined detection of CA125,CA199,CA72-4,and CEA in the diagnosis of gastrointestinal tumors was higher than that of the individual detection of the above four indicators,and the difference was statistically significant(P<0.01).Conclusions:The combined detection of CA125,CA199,CA72-4,and CEA in patients with gastrointestinal tumors can provide a basis for clinical diagnosis of gastrointestinal tumors,and can also accurately analyze their condition,which is beneficial for understanding the pathological differentiation and lymph node metastasis of tumors.