中西医结合治疗慢阻肺急性加重41例临床观察

Clinical Observation of 41 Cases of Acute Exacerbation of COPD Treated by Combination of Traditional Chinese and Western Medicine

目的:观察中西医结合治疗慢阻肺急性加重患者的临床疗效。方法:选择慢阻肺急性加重患者83例,用随机数字法分成对照组(n=42)、观察组(n=41)。对照组予西医常规治疗;观察组于此基础上予苏子降气汤加减辅助治疗,持续2周对比两组肺功能、血气分析指标及炎症反应。结果:两组治疗后FVC、PEF、FEV1均明显增加,且观察组FVC、PEF、FEV1较对照组的更高,有统计学差异(P<0.05);两组治疗后PaO_(2)、SaO_(2)均增高,PaCO_(2)均降低,且观察组PaO_(2)、SaO_(2)较对照组的更高,PaCO_(2)较对照组的更低,有统计学差异(P<0.05);两组治疗后TNF-α、IL-8、IL-6均明显降低,且观察组TNF-α、IL-8、IL-6较对照组的更低,有统计学差异(P<0.05)。治疗期间,两组均未发生严重不良反应。结论:中西医结合治疗AECOPD可改善患者血气分析指标,抑制炎症反应,改善肺功能。

Objective To investigate the clinical observation of 41 cases of acute copd exacerbation(AECOPD)treated by integrated Chinese and Western medicine.Methods 83 patients with AECOPD in our hospital were selected and divided into control group(n=42)and observation group(n=41)by random number method.The control group was treated with conventional Western medicine,and the observation group was treated with Suzi Jiangqi decoction for 2 weeks.The lung function,blood gas analysis index and inflammatory response of the two groups were compared.Results After treatment,FVC,PEF and FEV1 increased significantly in both groups,and FVC,PEF and FEV1 in treatment group were higher than those in conventional group,with statistical difference(P<0.05).PaO_(2) and SaO_(2) increased and PaCO_(2) decreased in both groups after treatment,and PaO_(2) and SaO_(2) in the treatment group were higher than those in the conventional group,and PaCO_(2) was lower than those in the conventional group,with statistical difference(P<0.05).After treatment,TNF-α,IL-8 and IL-6 were significantly decreased in both groups,and the levels of TNF-α,IL-8 and IL-6 in the treatment group were lower than those in the conventional group,with statistical difference(P<0.05).No serious adverse reactions occurred in both groups during treatment.Conclusion The combination of traditional Chinese and western medicine in treating AECOPD can improve blood gas analysis index,inhibit inflammatory response and improve lung function.