代谢综合征与幽门螺杆菌感染、尿酸的相关性分析

Correlation analysis of metabolic syndrome with Helicobacter pylori infection and uric acid

目的:调查代谢综合征(metabolic syndrome,MS)发生率、幽门螺杆菌(Helicobacter pylori,Hp)感染率;分析MS与Hp感染、尿酸(uric acid,UA)的相关性。方法:选取福建医科大学附属漳州市医院2022年1月至9月有测定Hp、UA等指标的住院患者305例,分为MS组与non-MS组、Hp(+)组与Hp(-)组,比较组间血压、血糖等指标的差异。二元Logistic回归模型分析MS的危险因素及Hp感染与年龄、性别的相关性。结果:MS发生率为15.41%;Hp感染率为44.92%。MS组与non-MS组两组年龄、男性患者比率、Hp感染率、UA、体重指数(body mass index,BMI)、甘油三酯(triglyceride,TG)、血糖、血压、高密度脂蛋白(high-density lipoprotein cholesterol,HDL-C)差异有统计学意义。Hp(+)组与Hp(-)组两组年龄、MS发病率、UA、BMI、超重率、TG、高TG血症发病率、血压、高血压发病率、HDL-C、低HDL-C血症发病率差异有统计学意义(P<0.05)。年龄是Hp感染的独立影响因素。Hp感染、男性、HDL-C、血糖、舒张压(diastolic blood pressure,DBP)、BMI是MS的独立影响因素。结论:男性MS发病率高于女性,年龄越大发病率越高。Hp感染与性别关系不明显,年龄越大感染率越高。Hp感染、男性等是MS的独立影响因素,UA不是MS的独立影响因素。

Objective:To investigate the prevalence of metabolic syndrome(MS)and Helicobacter pylori(Hp)infection,and to analyze the relationship between MS and Hp infection,uric acid(UA).Methods:A total of 305 patients with HP infection and UA were selected from the Zhangzhou Affiliated Hospital of Fujian Medical University from January 2022 to September 2022,they were divided into the MS Group and non-MS Group,HP(+)group and HP(-)group.BP and blood glucose were compared between groups.Binary logistic regression model was used to analyze the risk factors of MS and the relationship between Hp infection and age and sex.Results:The incidence of MS and Hp infection was 15.41%and 44.92%respectively.There were significant differences in age,male ratio,Hp infection rate,UA,BMI,TG,blood glucose,BP and HDL-C between the MS Group and the non-MS Group(P<0.05).There were significant differences in age,MS ratio,UA,BMI,overweight,TG,hypertriglyceridemia,BP,hypertension,HDL-C and low HDL-C between Hp(+)group and Hp(-)group(P<0.05).Age was an independent risk factor for Hp infection.Hp infection,male gender,HDL-C,blood glucose,DBP and BMI were independent risk factors for MS.Conclusion:The incidence of MS in male is higher than that in female.The relationship between Hp infection and sex is not obvious,but the infection rate increases with higher age.Hp infection and male are independent risk factors for MS,while UA was not.