基于数据挖掘中医药治疗慢性前列腺炎临床用药规律分析

An analysis of medication rules of traditional Chinese medicine on chronic prostatitis based on data mining

目的:运用数据挖掘方法分析近二十年来临床研究文献中中医药治疗慢性前列腺炎处方的用药规律。方法:检索2002年2月-2022年2月万方数据库、中国知网、维普资讯库中关于中医药治疗慢性前列腺炎的文献,根据纳入与排除标准筛选中医药治疗慢性前列腺炎的处方,运用Microsoft Excel 2021 MSO软件建立治疗慢性前列腺炎处方的数据库,在Window操作平台分别采用Weka 3.8软件和IBM SPSS Statistics 23软件对数据进行关联规则分析和对中药进行可视化中心度分析。结果:共纳入方剂227首,中药217味。用药频次≥30次的中药有28味,其中用药频次居前5位的药物为丹参、黄柏、牛膝、甘草、王不留行。治疗慢性前列腺炎所用中药的性味以性寒味苦为主,多归肝经、肾经、胃经,药物功效分类以活血化瘀药、清热药和利水渗湿药为主。关联规则分析得到20个药物组合,置信度最高的药物组合分别是“石菖蒲→萆薢”“红花→桃仁”“泽兰→丹参”。聚类分析得到3个核心药物组合。结论:中医药治疗慢性前列腺炎以清热利湿、活血化瘀为主,辅以补肾温阳、疏肝理气。挖掘得到的用药组合的组方规律契合其病机特点,对治疗慢性前列腺炎的方药组合和新药开发具有一定的参考价值。

Objective: The objective of this study is to analyze the medication rules of traditional Chinese medicine in the clinical research literature on chronic prostatitis in the past two decades. Methods: From February 2002 to February 2022, the relevant literature on the treatment of chronic prostatitis in traditional Chinese medicine was searched in Wanfang Data, CNKI, VIP. According to the inclusion and exclusion criteria, the prescriptions of traditional Chinese medicine for the treatment of chronic prostatitis were screened. The Microsoft Excel 2021 MSO software was used to establish a database of prescriptions for the treatment of chronic prostatitis, and the Weka 3.8 software and IBM SPSS Statistics 23 software were used to analyze the correlation rules and visualize the centrality of traditional Chinese medicines on the Window operation platform. Results: A total of 227 prescriptions and 217 flavors of traditional Chinese medicine were included. There were 28 flavors of traditional Chinese medicine with a frequency of not ess chan 30 times, of which the top 5 drugs with the highest frequency of medication were Danshen(Radix et Rhizoma Salviae Miltiorrhizae), Huangbo(Cortex Phellodendri Chinsis), Niuxi(Radix Achyranthis Bidentatae), Gancao(Radix Glycyrrhizae), and Wangbuliuxing(Semen Vaccariae). The tastes of traditional Chinese medicine used in the treatment of chronic prostatitis were mainly bitter and cold. Channel tropism mostly belonged to the liver meridian, kidney meridian, stomach meridian. According to the classification of drug efficacy, the drugs used were mainly blood activating stasis drugs, antipyretic drugs, and water infiltration drugs. The association rule analysis yielded 20 drug combinations, and the drug combinations with the highest confidence were “Shichangpu(Rhizoma Acori Tatarinowiis)→Bixie(Rhizoma Dioscoreae Septemlobae)” “Honghua(Flos Carthami)→Taoren(Semen Persicae)”, “Zelan(Herba Lycopi)→ Danshen(Radix et Rhizoma Salviae Miltiorrhizae)”. Cluster analysis yielded 3 core drug combinations. Conclusion: The treatment of chronic prostatitis in traditional Chinese medicine mainly focuses on clearing heat and dampness, and activating blood circulation and removing blood stasis, and takes tonifying kidney and warming Yang(阳), and soothing liver and regulating Qi(气)as auxiliary treatment measures. The drug combinations mined in this study are consistent with the characteristics of its pathogenesis, and have certain reference value for the combination of prescriptions and drugs and the development of new drugs for the treatment of chronic prostatitis.