慢性阻塞性肺疾病相关性肾损伤发生机制研究进展

Advances in the mechanism of chronic obstructive pulmonary disease-associated kidney injury

慢性阻塞性肺疾病(COPD)是一种以持续存在的呼吸道症状和气流受限为特征的疾病,除呼吸道病变以外,其还存在多种合并症。肾损伤是COPD重要的肺外合并症之一,发病率高,起病隐匿,不及时干预将进展为慢性肾病,极大地增加了COPD患者的死亡风险和经济负担。肺与肾生理上相互联系,病理上相互影响,但COPD相关性肾损伤的发生机制尚不明确。本文针对COPD相关性肾损伤发生机制的研究进展进行综述,以期为COPD相关性肾损伤的临床防治及基础研究提供参考。

Chronic obstructive pulmonary disease(COPD)is a disease characterized by persistent respiratory symptoms and airflow limitation,and also associated with a variety of comorbidities.As one of the important extrapulmonary comorbidities of COPD,kidney injury has a high incidence and insidious onset,which will develop into chronic kidney disease without timely intervention,greatly increasing the risk of mortality and economic burden of COPD patients.There exist physiological and pathological relations between lung and kidney functions.However,the mechanisms underlying COPD-associated kidney injury remain unclear.This article provides a review of the research progress on the mechanisms of COPD-associated kidney injury,in order to provide reference for the clinical prevention and treatment and basic research.