骨关节炎疼痛机制及相关中药治疗研究进展

Research progress of osteoarthritis pain mechanism and related traditional Chinese medicine treatment

骨关节炎(OA)是目前临床最常见的退行性疾病,关节疼痛是OA的主要表现,严重时可导致关节畸形,主要病理改变包括关节软骨破坏、滑膜炎、软骨下骨增厚、骨赘形成、关节韧带退变和关节包膜肥大。OA患者的临床病理变化和疼痛程度因人而异,治疗方案也因人而异。目前临床中治疗OA患者疼痛的药物为非甾体抗炎药,但效果并不理想,且长期使用会带来明显的毒副作用,中医药在缓解OA患者疼痛方面具有较好的效果。因此,本文对OA的中药治疗及疼痛机制的研究进行综述,以期为临床缓解OA疼痛提供思路和参考。

Osteoarthritis(OA)is the most common degenerative disease in clinical practice.Joint pain is the main manifestation of OA,and in severe cases,it can lead to joint deformity.The main pathological changes include destruction of articular cartilage,synovitis,thickening of subchondral bone,bone redundancy,degeneration of articular ligaments,and enlargement of articular periosteum.Clinicopathological changes and pain degrees in OA patients vary from person to person,and treatment options vary from person to person.Clinically,non-steroidal anti-inflammatory drugs are used to treat the pain of OA patients now,but the effect is not ideal,and long-term use of these drugs will bring obvious toxic and side effects.Traditional Chinese medicine obtains good results in relieving the pain of OA patients.Therefore,this paper reviews the research on traditional Chinese medicine treatment and pain mechanisms of OA,with a view to providing ideas and references for clinical relief of pain in OA patients.