血液透析治疗对慢性肾脏病合并心血管疾病患者微炎性因子及血管钙化的影响

Effect of Hemodialysis on Microinflammatory Factors and Vascular Calcification in Patients with Chronic Kidney Disease Complicated with Cardiovascular Disease

目的:分析血液透析治疗对慢性肾脏病合并心血管疾病患者微炎性因子及血管钙化的影响。方法:选取2021年7月—2023年3月菏泽市成武县人民医院肾病内科收治的慢性肾脏病患者100例作为研究对象,根据是否合并心血管疾病分为对照组(未合并,50例)、观察组(合并,50例)。两组患者均进行血液透析治疗,比较两组微炎性因子、血管钙化相关指标。结果:微炎性因子方面,治疗后,两组C反应蛋白、瘦素水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。血管钙化相关指标方面,治疗后,两组血磷、甲状旁腺激素水平低于治疗前,且观察组低于对照组,两组钙化积分高于治疗前,且观察组高于对照组(P<0.05)。观察组血管钙化发生率比对照组高,差异有统计学意义(P<0.05)。结论:慢性肾脏病合并心血管疾病患者在接受血液透析治疗时更容易出现血管钙化问题,且具有较高微炎性因子水平,在血液透析治疗时,可通过上述指标来判断患者心血管疾病发生风险,对临床指导工作具有重要作用。

Objective:To analyze the effect of hemodialysis treatment on microinflammatory factors and vascular calcification in patients with chronic kidney disease complicated with cardiovascular disease.Methods:A total of one hundred patients with chronic kidney disease admitted to the nephrology department of Heze Chengwu County People's Hospital from July 2021 to March 2023 were selected as the study objects,and were divided into control group(50 cases without complications)and observation group(50 cases with complications)according to whether they had cardiovascular disease.Both groups underwent hemodialysis treatment.Microinflammatory factors and vascular calcification related indexes were compared between the two groups.Results:In terms of micro-inflammatory factors,after treatment,the levels of C-reactive protein and leptin in two groups were higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05);in terms of indicators related to vascular calcification,after treatment,the levels of blood phosphorus and parathyroid hormone in two groups were lower than before treatment,and the observation group was lower than the control group,the calcification score of the two groups was higher than before treatment,and the observation group was higher than the control group(P<0.05);the incidence of vascular calcification in observation group was higher than that in control group,and the difference was statistically significant(P<0.05).Conclusion:Patients with chronic kidney disease complicated with cardiovascular disease are more prone to vascular calcification and have higher levels of microinflammatory factors when receiving hemodialysis treatment.During hemodialysis treatment,the risk of cardiovascular disease in patients can be judged by the above indicators,which will play an important role in clinical guidance.