残余胆固醇与慢性胆囊炎相关性研究

Correlation study between residual cholesterol and chronic cholecystitis

目的探讨残余胆固醇(RC)与慢性胆囊炎之间的相关性。方法回顾性选择2024年1—5月在某三甲医院健康管理中心进行健康体检的19587名体检者为研究对象,通过超声检查结果评估慢性胆囊炎,分为慢性胆囊炎组(2816例)和非慢性胆囊炎组(16771例),采用Spearman秩相关分析探讨RC与慢性胆囊炎发病的其他危险因素的相关性,采用二元Logistic回归分析(向前法)探讨RC是否为慢性胆囊炎的独立危险因素。结果Spearman秩相关分析显示,残余胆固醇与收缩压、舒张压、体重指数、空腹血糖、淋巴细胞百分比、总胆固醇、甘油三酯、甘油三酯、白/球蛋白、总胆红素、尿酸、肌酐呈正相关(rs=0.078、0.111、0.114、0.102、0.019、0.247、0.440、0.133、0.024、0.074、0.093,P<0.05);与中性粒细胞百分比、高密度脂蛋白、低密度脂蛋白、总胆红素、白蛋白、球蛋白、尿素氮负相关(rs=-0.017、-0.258、-0.059、-0.192、-0.052、-0.177、-0.043,P<0.05);与脉压差、血小板无相关关系(rs=0.009、-0.010,P>0.05)。二元Logistic回归分析显示,年龄(OR=1.035,95%CI=1.031~1.038)、婚否(OR=1.942,95%CI=1.357~2.780)、肥胖(OR=1.145,95%CI=1.012~1.295)、残余胆固醇(OR=1.116,95%CI=1.025~1.216)、血脂异常(OR=1.090,95%CI=1.001~1.187)、肌酐(OR=1.003,95%CI=1.001~1.005)是慢性胆囊炎发病的独立危险因素(P<0.05)。结论慢性胆囊炎的发生与RC有关,RC是慢性胆囊炎发病的独立危险因素。

Objective To investigate the correlation between residual cholesterol(RC)and chronic cholecystitis.Methods A retrospective study was conducted on 19,587 individuals who underwent health examinations at a tertiary hospital's health management center from January 2024 to May 2024.Chronic cholecystitis was assessed via ultrasound examination,and participants were divided into chronic cholecystitis group(2,816 cases)and non-chronic cholecystitis group(16,771 cases).Spearman's rank correlation analysis was utilized to explore the correlation between RC and other risk factors for chronic cholecystitis,and binary logistic regression analysis(forward stepwise method)was conducted to determine whether RC is an independent risk factor for chronic cholecystitis.Results The Spearman rank correlation analysis showed that,residual cholesterol positively with systolic blood pressure,diastolic blood pressure,body mass index,fasting blood glucose,lymphocyte percentage,total cholesterol,triglyceride,triglycerides,total bilirubin,uric acid,creatinine(r s=0.078,0.111,0.114,0.102,0.019,0.247,0.440,0.133,0.024,0.074,0.093,P<0.05);Negatively correlation with the percentage of neutrophils,high density lipoprotein,low density lipoprotein,total bilirubin,albumin,globulin,and urea nitrogen(r s=-0.017,-0.258,-0.059,-0.192,-0.052,-0.177,-0.043,P<0.05).There was no relationship with differential pulse pressure and platelets(r s=0.009,-0.010,P>0.05).Binary Logistic regression analysis showed that,Age(OR=1.035,95%CI=1.031~1.038),marriage(OR=1.942,95%CI=1.357~2.780),obesity(OR=1.145,95%CI=1.012~1.295),residual cholesterol(OR=1.116,95%CI=1.025~1.216),dyslipidemia(OR=1.090,95%CI=1.001~1.187),creatinine(OR=1.003,95%CI=1.001 to 1.005)were independent risk factor for the onset of chronic cholecystitis(P<0.05).Conclusions The occurrence of chronic cholecystitis is related to RC,and RC is an independent risk factor for the onset of chronic cholecystitis.