基于Web of Science数据库的抗结核药物研究进展与趋势

Research progress and trends in anti-tuberculosis drug based on Web of Science database

目的探究抗结核药物研究的热点及发展趋势。方法通过Web of Science数据库检索2004年1月—2024年5月发布的有关抗结核药物研究的文献,并采用CiteSpace 6.1.R2软件对收集的数据进行知识图谱的可视化分析,涉及作者、国家、机构和关键词等多个维度。结果研究发现该领域的发文量呈现波动性增长。美国、印度和中国的发文量居前,对该研究领域的贡献尤为突出。高等院校和国家级研究机构构成了该领域研究的主力。首都医科大学和中国医学科学院在我国的抗结核研究中作出了显著贡献。研究热点主要围绕耐药性结核病、新药设计、肝毒性和群体药代动力学等方面展开。结论发现新药物作用机制和靶点、实施个性化医疗与精准治疗、利用生物技术和纳米技术提升药物递送系统的效率,以及整合信息技术,这些都是当前抗结核药物研究的核心方向。通过这些策略的综合运用,抗结核药物的研发可以实现多样化和效率化,进而有效地控制结核病的传播和治疗。通过对抗结核药物研究现状的全面分析,为未来该领域的研究方向和政策制定提供了重要参考。

Objective To explore the research hotspots and development trends in the field of anti-tuberculosis drugs.Methods Literature related to anti-tuberculosis drug research published from January 2004 to May 2024 was retrieved from the Web of Science database.CiteSpace 6.1.R2 software was used to perform a visual analysis of the knowledge map,involving multiple dimensions such as authors,countries,institutions,and keywords.Results The publication volume in this field showed a fluctuating growth trend.The United States,India,and China lead in publication numbers and make significant contributions to the field.Higher education institutions and national research organizations form the backbone of research in this area.Capital Medical University and the Chinese Academy of Medical Sciences have made notable contributions to anti-tuberculosis research in China.Research hotspots mainly revolve around drug-resistant tuberculosis,new drug design,hepatotoxicity,and population pharmacokinetics.Conclusions Discovering new drug mechanisms and targets,implementing personalized and precision medicine,enhancing drug delivery systems through biotechnology and nanotechnology,and integrating information technology are core directions in current anti-tuberculosis drug research.By employing these strategies comprehensively,the development of anti-tuberculosis drugs can be diversified and made more efficient,effectively controlling the spread and treatment of tuberculosis.A comprehensive analysis of the current state in this field provides vital references for future research directions and policy formulation.