血清ITLN-1、CD137、CEACAM1水平在急性心肌梗死患者中的变化及其联合检测对MACE发生的预测效能

Changes of Serum ITLN-1,CD137,CEACAM1 Levels in Patients with Acute Myocardial Infarction and the Predictive Efficacy of Combined Detection for MACE

目的探讨血清凝集蛋白1(ITLN-1)、白细胞分化抗原137(CD137)、癌胚抗原相关细胞黏附分子1(CEACAM1)在急性心肌梗死(AMI)患者中的变化及其联合检测对主要不良心血管事件(MACE)的预测效能。方法回顾性收集2022年2月—2023年1月南阳医学高等专科学校第一附属医院收治的采用经皮冠状动脉介入术(PCI)100例AMI患者临床资料,作为病例组;另收集同期100名健康体检人群临床资料,作为对照组。病例组患者根据PCI术6个月内是否发生MACE分为发生组与未发生组。比较病例组与对照组、发生组与未发生组血清ITLN-1、CD137、CEACAM1水平差异,使用Pearson相关性检验血清ITLN-1、CD137、CEACAM1与AMI患者发生MACE的相关性,绘制受试者工作特征曲线(ROC)评估血清ITLN-1、CD137、CEACAM1联合检测对AMI患者发生MACE的预测效能。结果病例组血清ITLN-1低于对照组,血清CD137、CEACAM1高于对照组(P<0.05)。100例患者中32例发生MACE,发生率为32.00%(32/100)。发生组血清ITLN-1低于未发生组,血清CD137、CEACAM1高于未发生组(P<0.05)。绘制ROC曲线,结果显示血清ITLN-1、CEACAM1对AMI患者PCI后发生MACE预测价值较低,AUC分别为0.650、0.689,CD137与三者联合检测具有良好的预测价值,其中以联合预测价值最高,AUC分别为0.771、0.836。结论AMI患者血清ITLN-1呈现出下降趋势,CD137、CEACAM1呈现出上升趋势,血清ITLN-1、CD137、CEACAM1三者联合检测对AMI患者PCI后发生MACE具有良好的预测价值。

Objective To investigate the changes of serum intelectin-1(ITLN-1),cluster of differentiation 137(CD137)and carcinoembryonic antigen-related cellular adhesion molecule 1(CEACAM1)in patients with acute myocardial infarction(AMI)and the predictive power of their combined detection for major adverse cardiovascular events(MACE).Methods The clinical data of 100 patients with AMI who underwent percutaneous coronary intervention(PCI)in First Affiliated Hospital of Nanyang Medical College from February 2022 to January 2023 were collected retrospectively as a case group.The clinical data of 100 healthy people in the same period were collected as the control group.The patients in the case group were divided into the occurrence group and the non-occurrence group according to whether MACE occurred within 6 months after PCI.The levels of serum ITLN-1,CD137 and CEACAM-1 were compared between the case group and the control group,and between the occurrence group and the non-occurrence group.Pearson correlation was used to test the correlation between serum ITLN-1,CD137 and CEACAM-1 and the occurrence of MACE in AMI patients,and receiver operating characteristic curve(ROC)was drawn to evaluate the predictive power of combined detection of serum ITLN-1,CD137 and CEACAM-1 in AMI patients.Results Serum ITLN-1 in the case group was lower than that in the control group,and serum CD137 and CEACAM1 were higher than those in the control group(P<0.05).Among 100 patients,32 cases developed MACE,and incidence rate was 32.00%(32/100).Serum ITLN-1 was lower in the occurrence group than in the non-occurrence group,and serum CD137 and CEACAM1 were higher than in the non-occurrence group(P<0.05).ROC curve was drawn.Results showed that serum ITLN-1 and CEACAM1-1 had low predictive value for the occurrence of MACE in AMI patients after PCI,with AUC of 0.650 and 0.689 respectively.CD137 and combined detection of the three indicators had good predictive value,among which the combined predictive value was the highest,with AUC of 0.771 and 0.836 respectively.Conclusion Serum ITLN-1 in AMI patients shows a downward trend,while CD137 and CEACAM1 show an upward trend.The combined detection of serum ITLN-1,CD137 and CEACAM1 has a good predictive value for the occurrence of MACE in AMI patients after PCI.