半夏泻心汤加味治疗痰湿壅盛型高血压临床研究

Clinical Study on the Treatment of Phlegm-damp Congestion and Excessiveness Type Hypertension with Modified Banxia Xiexin Decoction

目的探究半夏泻心汤加味治疗痰湿壅盛型高血压的临床疗效。方法采用随机数字表法将98例痰湿壅盛型高血压患者分为对照组和试验组,每组49例。对照组予以常规西药治疗,试验组在对照组基础上加用半夏泻心汤加味治疗,2组均治疗1个月。比较2组临床总有效率、中医证候积分、血压、血脂[甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)]、炎症因子[同型半胱氨酸(homocysteine,Hcy)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白细胞介素-6(interleukin-6,IL-6)]等指标。结果治疗后,试验组总有效率为93.88%,高于对照组的79.59%(P<0.05)。2组中医证候积分、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)均较治疗前降低(P均<0.05),且试验组上述指标均低于对照组(P均<0.05)。2组TG、TC、LDL-C、Hcy、hs-CRP、IL-6均较治疗前降低(P均<0.05),且试验组上述指标均低于对照组(P均<0.05)。治疗过程中,试验组不良反应发生率为8.16%,与对照组的18.37%比较,差异无统计学意义(P>0.05)。结论半夏泻心汤加味治疗痰湿壅盛型高血压可提高临床疗效,改善中医证候积分,促进降压,调节血脂,并抑制炎症反应,安全性良好,值得推广。

Objective To investigate the clinical efficacy of modified Banxia Xiexin decoction in treating hypertension with phlegm-damp congestion and excessiveness.Methods A total of 98 patients with phlegm-damp congestion and excessiveness type hypertension were randomly divided into the control group and the trial group using a random number table method,with 49 cases in each group.The control group was treated with conventional western medicine,while the trial group was treated with modified Banxia Xiexin decoction on the basis of the control group.Both groups were treated for one month.The clinical total effective rate,traditional Chinese medicine syndrome scores,blood pressure,blood lipids[triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)],inflammatory factors[homocysteine(Hcy),hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)]were compared between the two groups.Results After treatment,the total effective rate of the trial group was 93.88%,which was higher than the 79.59%of the control group(P<0.05).The scores of traditional Chinese medicine syndrome,systolic blood pressure(SBP)and diastolic blood pressure(DBP)in both groups decreased compared to those before treatment(all P<0.05),and the above indicators in the trial group were lower than those in the control group(all P<0.05).TG,TC,LDL-C,Hcy,hs-CRP and IL-6 in both groups decreased compared to those before treatment(all P<0.05),and the above indicators in the trial group were lower than those in the control group(all P<0.05).During the treatment process,the incidence rate of adverse reactions in the trial group were 8.16%.Compared to the 18.37% in the control group,the difference was not statistically significant(P>0.05).Conclusion The modified Banxia Xiexin decoction could improve clinical efficacy and traditional Chinese medicine syndrome scores,promote blood pressure reduction,regulate blood lipids,and inhibit inflammatory reactions in the treatment of phlegm-damp congestion and excessiveness type hypertension.It has good safety and is worth promoting.