美托洛尔联合胺碘酮对冠心病合并室性早搏的疗效及心率变异性的影响

Efficacy of metoprolol combined with amiodarone on coronary heart disease complicating premature ventricular contraction and its influence on heart rate variability

目的 分析美托洛尔联合胺碘酮治疗冠心病合并室性早搏的效果。方法 选取198例冠心病合并室性早搏患者,按随机数字表法分为对照组和观察组两组,每组各99例。对照组口服胺碘酮治疗,观察组采用胺碘酮加美托洛尔口服治疗,两组疗程均为1个月。对比两组临床疗效、动态心电图参数、心率变异性(heart rate variability, HRV)指标、心功能指标及不良反应的发生情况。结果 观察组治疗总有效率明显高于对照组,且治疗后的QT间期离散度、校正的QT间期离散度均明显低于对照组,各项HRV指标、心功能指标均优于对照组(均P<0.05);两组治疗期间均未出现不良反应。结论 在使用胺碘酮的基础上加用美托洛尔治疗冠心病合并室性早搏,可进一步改善患者的HRV指标和心功能,显著提高疗效,值得在临床推广。

Objective To analyze the efficacy of metoprolol combined with amiodarone in the treatment of coronary heart disease(CHD)complicating premature ventricular contraction(PVC).Methods A total of 198 patients with CHD complicating PVC were divided into control and observation groups in the random number table method,with 99 cases in each group.The control group was treated with amiodarone while the observation group was treated with amiodarone combined with metoprolol following oral administration.The course of medication was both one month in the two groups.The clinical efficacy,ambulatory electrocardiography(AECG)indexes,heart rate variability(HRV)indexes,cardiac function indicators,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group;QT interval dispersion and corrected QT interval dispersion after treatment were both lower than those in the control group while each HRV index and cardiac function indicator were all better than those in the control group(all P<0.05).There was no adverse reaction during treatment in both groups.Conclusion Metoprolol plus amiodarone could further improve HRV indexes and cardiac function in CHD patients complicated by PVC,and significantly promote the efficacy.It is worthy of clinical promotion and application.