内皮细胞衰老与血管功能障碍

Endothelial cell senescence and vascular dysfunction

内皮细胞衰老越来越被认为是血管功能障碍和年龄相关疾病发展的重要因素。众所周知,内皮细胞衰老的发生涉及多方面因素,且内皮细胞衰老与血管功能障碍相互影响。该综述概括了内皮细胞衰老的表型改变特点,就内皮细胞衰老与血管舒缩功能障碍、血管屏障功能受损、血管炎症等多种血管功能障碍之间的关系进行阐述,旨在为延缓人体血管衰老、改善血管功能提供参考。

Endothelial cell senescence is increasingly recognized as an important factor in the development of vascular dysfunction and age-related diseases.As is well known,the occurrence of endothelial cell senescence involves multiple factors,and endothelial cell senescence and vascular dysfunction interact with each other.This review summarized the phenotypic changes of endothelial cell senescence,and reviewed the relationship between endothelial cell senescence and various vascular dysfunction,such as dysfunction of vascular relaxation and contraction,impaired vascular barrier function,and vasculitis.The aim is to provide reference for delaying human vascular aging and improving vascular function.