摘要
目的:探讨健脾止泻汤辅助地衣芽孢杆菌活菌颗粒、西咪替丁治疗轮状病毒性肠炎(Rotavirus enteritis,RVE)患儿的临床疗效。方法:选取医院2023年1月至2023年12月收治的RVE患儿108例,随机分为常规西药组和中药辅助组,各54例。常规西药组给予地衣芽孢杆菌活菌颗粒和西咪替丁治疗,中药辅助组在常规西药组基础上采用健脾止泻汤辅助治疗。治疗7 d后比较两组疗效、症状改善情况、不良反应及治疗前后炎性因子白细胞介素-6(Interleukin,IL-6)、高敏C反应蛋白(Highly sensitive C-reactive protein,hs-CRP)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、晚期糖基化终末产物(Advanced glycation end products,AGEs)、肠道菌群(双歧杆菌、大肠埃希菌、乳杆菌)、肠黏膜屏障(D-乳酸、二胺氧化酶、内毒素)。结果:治疗7 d后,较常规西药组相比,中药辅助组总有效率较高为92.59%(P<0.05);止泻、退热、脱水纠正时间较短(P<0.05);双歧杆菌、乳杆菌数量较高而大肠埃希菌数量较低(P<0.05);并且血清hs-CRP、IL-6、TNF-α、AGEs、D-乳酸、二胺氧化酶、内毒素水平均较低(P<0.05);治疗期间,两组不良反应发生率无明显差异(P>0.05)。结论:健脾止泻汤辅助地衣芽孢杆菌活菌颗粒、西咪替丁治疗RVE具有较好的临床疗效,可有效缓解病情,保护患儿的肠黏膜屏障,减轻炎症损伤,调节肠道菌群,且具有较高的用药安全性。
Objective:To investigate the clinical efficacy of Jianpi Zhixie decoction assisting live Bacillus licheniformis granules and cimetidine in the treatment of rotavirus enteritis(RVE)children.Methods:A total of 108 children with RVE admitted to our hospital from January 2023 to December 2023 were divided into conventional western medicine group and traditional Chinese medicine(TCM)auxiliary group by random number table method,54 cases in each group.The conventional western medicine group was treated with live Bacillus licheniformis granules and cimetidine,and the TCM auxiliary group was treated with Jianpi Zhixie decoction based on the conventional western medicine group.After 7 days of treatment,the efficacy,symptom improvement,adverse reactions,and inflammatory factors interleuin(IL-6),highly sensitive C-reactive protein(hs-CRP),Tumor necrosis factor-α(TNF-α),advanced glycation end products(AGEs),intestinal flora(Bifidobacterium,Escherichia coli,Lactobacillus),intestinal mucosal barrier(D-lactic acid,diamine oxidase,endotoxin)were compared between the two groups.Results:After 7 days of treatment,compared with conventional western medicine group,the total effective rate of TCM auxiliary group was higher 92.59%(P<0.05);the correction time of diarrhea,fever and dehydration were shorter(P<0.05);the quantity of Bifidobacterium and Lactobacillus were higher,and the quantity of Escherichia coli was lower(P<0.05);the serum levels of hs-CRP,IL-6,TNF-α,AGEs,D-lactic acid,diamine oxidase and endotoxin were lower(P<0.05).During treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Jianpi Zhixie decoction assisting live Bacillus heniformis granules and cimetidine have good clinical efficacy in the treatment of RVE,which can effectively alleviate the disease,protect the intestinal mucosal barrier of children,reduce inflammation and damage,regulate intestinal flora,and have high drug safety.
作者
黄欢娣
谢春丹
汪奇伟
Huang Huan-di;Xie Chun-dan;Wang Qi-wei(Department of Pediatrics,The First People’s Hospital of Xiangfu District,Kaifeng 475000,Henan,China;Department ofPediatrics,Huaihe Hospital,Henan University,Kaifeng 475000,Henan,China)
