复方甲氧那明联合盐酸西替利嗪对咳嗽变异性哮喘患者血气分析指标及血清炎症因子水平的影响

Effects of compound methoxyamine combined with Cetirizine hydrochloride on blood gas analysis indexes and serum inflammatory factors in patients with cough variant asthma

目的:探讨复方甲氧那明联合盐酸西替利嗪对咳嗽变异性哮喘(Cough variant asthma,CVA)患者血气分析指标及血清炎症因子水平的影响。方法:回顾性收集2022年1月至2024年3月期间本院收治的CVA患者71例作为研究对象。按治疗方法的不同,将患者分为对照组(盐酸西替利嗪治疗,n=34)和观察组(复方甲氧那明联合盐酸西替利嗪治疗,n=37)。对照组采用盐酸西替利嗪口服溶液10 mg·次^(-1)治疗,观察组基于对照组加用复方甲氧那明2粒·次^(-1)口服治疗,两组持续用药1 m。分析比较两组的临床疗效、症状改善程度,于治疗前后采用全自动血气分析仪检测动脉血氧饱和度(Arterial oxygen saturation,SaO_(2))、动脉血氧分压(Arterial partial pressure of oxygen,PaO_(2))、动脉血二氧化碳分压(Arterial blood carbon dioxide partial pressure,PaCO_(2)),并采用双抗夹心法检测白介素-4(Interleukin-4,IL-4)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、神经营养素-3(Neurotrophin-3,NT-3)、干扰素-γ(Interferon-γ,IFN-γ)水平,分析对比两组不良反应发生率。结果:观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,观察组的气喘、咽痒、咳痰、咳嗽各项症状积分均显著低于对照组(P<0.05)。治疗后,观察组的PaCO_(2)显著低于对照组,PaO_(2)、SaO_(2)显著高于对照组(P<0.05)。治疗后,观察组的IL-4、TNF-α、NT-3显著低于对照组,IFN-γ显著高于对照组(P<0.05)。两组的不良反应发生率无显著差异(P>0.05)。结论:复方甲氧那明联合盐酸西替利嗪治疗CVA患者,能提高临床治疗果,减轻临床症状,改善血气指标,降低机体炎性反应,且安全性较高。

Objective:To investigate the effects of compound methoxyamine combined with cetirizine hydrochloride on blood gas analysis indexes and serum inflammatory factors in patients with cough variant asthma(CVA).Methods:A retrospective collection of 71 patients with CVA admitted to our hospital from January 2022 to March 2024 was conducted as the research object.According to different treatment methods,patients were divided into a control group(treated with cetirizine hydrochloride,n=34)and an observation group(treated with compound methoxyphenamine hydrochloride combined with cetirizine hydrochloride,n=37).The control group was treated with cetirizine hydrochloride oral solution 10 mg·time-1,while the observation group was treated with compound methoxyphenamine hydrochloride 2 tablets·time-1 based on the control group.Both groups continued to take medication for 1 month.The clinical efficacy and symptom improvement of the two groups were analyzed and compared.Before and after treatment,the arterial oxygen saturation(SaO_(2)),arterial partial pressure of oxygen(PaO_(2)),and arterial blood carbon dioxide partial pressure(PaCO_(2))were measured using a fully automated blood gas analyzer.The levels of interleukin-4(IL-4),tumor necrosis factor-α(TNF-α),neurotrophin-3(NT-3),and interferon-γ(IFN-γ)were detected using a double antibody sandwich method.The incidence of adverse reactions in the two groups was analyzed and compared.Results:The total effective rate of observation group was significantly higher than that of control group(P<0.05).After treatment,the scores of asthma,pharyngeal itching,phlegm and cough in the observation group were significantly lower than those in the control group(P<0.05).After treatment,PaCO_(2)in observation group was significantly lower than that in control group,PaO_(2)and SaO_(2)were significantly higher than that in control group(P<0.05).After treatment,the levels of IL-4,TNF-αand NT-3 in observation group were significantly lower than those in control group,and the levels of IFN-γwere significantly higher than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Compound methoxyamine combined with cetirizine hydrochloride in the treatment of CVA patients can improve clinical results,alleviate clinical symptoms,improve blood gas indexes,reduce inflammatory response,and have high safety.